SynthesisDrugs2021
The Potential Role of Clinical Metagenomics in Infectious Diseases: Therapeutic Perspectives.
Synthesis in Drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What Is the Accuracy of 16S PCR Followed by Sanger Sequencing or Next-generation Sequencing in Native Vertebral Osteomyelitis? A Systematic Review and Meta-analysis.Clinical orthopaedics and related research · 2025Pooled it
- No detectable infectious agents in Langerhans cell histiocytosis with lung involvement.ERJ open research · 2026Article
- Precision metagenomics reveals microbial landscape in acute upper respiratory infections: a comprehensive dataset.BMC research notes · 2025Article
- Clinical application and impact of metagenomic next-generation sequencing for the diagnosis of infectious diseases in severely immunocompromised pediatric patients.BMC pediatrics · 2025Article
- Metagenomic analysis of human, animal, and environmental samples identifies potential emerging pathogens, profiles antibiotic resistance genes, and reveals horizontal gene transfer dynamics.Scientific reports · 2025Article
- Towards unraveling antimicrobial resistance dynamics: a longitudinal exploration of rectal swab metagenomes.BMC microbiology · 2025Article
- Predicting antibiotic resistance genes and bacterial phenotypes based on protein language models.Frontiers in microbiology · 2025Article
- Diagnostic value of metagenomic next generation sequencing of bronchoalveolar lavage fluid in immunocompromised patients with pneumonia.Frontiers in cellular and infection microbiology · 2025Article
- The untapped potential of vaginal microbiome diagnostics for improving women's health.Frontiers in cellular and infection microbiology · 2025Review
- Analysis of metagenomic data.Nature reviews. Methods primers · 2025Article
- Enhancing fever of unknown origin diagnosis: machine learning approaches to predict metagenomic next-generation sequencing positivity.Frontiers in cellular and infection microbiology · 2025Article
- Metagenomics Applied to the Respiratory Mycobiome in Cystic Fibrosis.Mycopathologia · 2024Review
- Nanopore R10.4 metagenomic detection of blaNature communications · 2024Article
- Analysis of pulmonary microecology and clinical characteristics of patients carrying human herpesvirus.Future microbiology · 2024Article
- Artificial intelligence applications in the diagnosis and treatment of bacterial infections.Frontiers in microbiology · 2024Review
- Current Uses and Future Perspectives of Genomic Technologies in Clinical Microbiology.Antibiotics (Basel, Switzerland) · 2023Review
- Diagnostic Performance and Clinical Impact of Metagenomic Next-Generation Sequencing for Pediatric Infectious Diseases.Journal of clinical microbiology · 2023Article
- What about the bull? A systematic review about the role of males in bovine infectious infertility within cattle herds.Veterinary and animal science · 2023Review
- Clinical metagenomics-challenges and future prospects.Frontiers in microbiology · 2023Review
- Assessing Surveillance of Wildlife Diseases by Determining Mammal Species Vulnerability to Climate Change.Transboundary and emerging diseases · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical metagenomics (CMg) is the process of sequencing nucleic acid of clinical samples to obtain clinically relevant information such as the identification of microorganisms and their susceptibility to antimicrobials. Over the last decades, sequencing and bioinformatic solutions supporting CMg have much evolved and an increasing number of case reports and series covering various infectious diseases have been published. Metagenomics is a new approach to infectious disease diagnosis that is currently being developed and is certainly one of the most promising for the coming years. However, most CMg studies are retrospective, and few address the potential impact CMg could have on patient management, including initiation, adaptation, or cessation of antimicrobials. In this narrative review, we have discussed the potential role of CMg in bacteriology, virology, mycology, and parasitology. Several reports and case-series confirm that CMg is an innovative tool with which one can (i) identify more microorganisms than with conventional methods in a single test, (ii) obtain results within hours, and (iii) tailor the antimicrobial regimen of patients. However, the cost-efficiency of CMg and its real impact on patient management are still to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.