Evidence map›Paper›PMID 34328565›Full record

ArticleEJNMMI physics2021

Optimization of SPECT/CT imaging protocols for quantitative and qualitative

Dennis Kupitz, Heiko Wissel, Jan Wuestemann, Stephanie Bluemel, Maciej Pech, Holger Amthauer, Michael C Kreissl, Oliver S Grosser

Abstract read
In one paragraph

Article in EJNMMI physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Optimisation of Q.Clear (BSREM) Reconstruction Parameters forBioengineering (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Fast [EJNMMI physics · 2026
    Article
  5. Quantitative Comparison of SPECT and PET Performance for Clinical Theranostic Applications.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. The value ofQuantitative imaging in medicine and surgery · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Experimental evaluation of absolute quantification inJournal of applied clinical medical physics · 2022
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dennis KupitzDepartment of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany. dennis.kupitz@med.ovgu.de.ORCID http://orcid.org/0000-0003-0761-4964
Heiko WisselDepartment of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
Jan WuestemannDepartment of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
Stephanie BluemelDepartment of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Maciej PechDepartment of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
Holger AmthauerDepartment of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Michael C KreisslDepartment of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
Oliver S GrosserDepartment of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe introduction of hybrid SPECT/CT devices enables quantitative imaging in SPECT, providing a methodological setup for quantitation using SPECT tracers comparable to PET/CT. We evaluated a specific quantitative reconstruction algorithm for SPECT data using a

resultsThe reconstructed activity concentration (AC

conclusionQuantitative SPECT imaging is feasible with the used reconstruction algorithm and hybrid SPECT/CT, and its consistent implementation in diagnostics may provide perspectives for quantification in routine clinical practice (e.g., assessment of bone metabolism). When combining quantitative analysis and diagnostic imaging, we recommend using two different reconstruction protocols with task-specific optimized setups (quantitative vs. qualitative reconstruction). Furthermore, individual scatter correction significantly improves both quantitative and qualitative results.

Indexed as

Image reconstructionOptimizationQuantitative SPECTScatter correctionSPECT/CT

Identifiers

PMID34328565
PMCPMC8324619

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.