Evidence map›Paper›PMID 34328547›Full record

ReviewMammalian genome : official journal of the International Mammalian Genome Society2022

INFRAFRONTIER quality principles in systemic phenotyping.

Hilke Ehlich, Heather L Cater, Ann M Flenniken, Isabelle Goncalves Da Cruz, Anne-Marie Mura, Vasileios Ntafis, Michael Raess, Mohammed Selloum, Claudia Stoeger, Sarka Suchanova and 14 more

Abstract readReview
In one paragraph

Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
  2. Review
  3. Article
  4. INFRAFRONTIER: mouse model resources for modelling human diseases.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Review
  5. What to consider for ECG in mice-with special emphasis on telemetry.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Hilke EhlichINFRAFRONTIER GmbH, Neuherberg, Germany.ORCID 0000-0002-9355-4832
Heather L CaterMRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire, UK.ORCID 0000-0002-8696-6070
Ann M FlennikenLunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.ORCID 0000-0003-1892-6154
Isabelle Goncalves Da CruzUniversite de Strasbourg, CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de La Souris, Illkirch, France.
Anne-Marie MuraCentre d'Immunophénomique (CIPHE), Aix Marseille Université, INSERM, CNRS, CELPHEDIA, PHENOMIN, Marseille, France.ORCID 0000-0002-8082-1583
Vasileios NtafisBiomedical Sciences Research Center "Alexander Fleming", Athens, Greece.
Michael RaessINFRAFRONTIER GmbH, Neuherberg, Germany.ORCID 0000-0002-8759-1186
Mohammed SelloumUniversite de Strasbourg, CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de La Souris, Illkirch, France.ORCID 0000-0003-4057-3519
Claudia StoegerHelmholtz Zentrum München, Institute of Experimental Genetics, German Mouse Clinic, Neuherberg, Germany.ORCID 0000-0001-8361-0274
Sarka SuchanovaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.ORCID 0000-0001-6723-300X
Reetta VuolteenahoUniversity of Oulu, Biocenter Oulu, Transgenic and Tissue Phenotyping Core Facility, Oulu, Finland.ORCID 0000-0001-6366-1082
Steve D M BrownMRC Harwell Institute, Mammalian Genetics Unit, Medical Research Council, Harwell Campus, Oxfordshire, UK.ORCID 0000-0002-0617-4824
Yann HéraultUniversite de Strasbourg, CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de La Souris, Illkirch, France.ORCID 0000-0001-7049-6900
Reetta HinttalaUniversity of Oulu, Biocenter Oulu, Transgenic and Tissue Phenotyping Core Facility, Oulu, Finland.ORCID 0000-0002-7642-4008
Martin Hrabě de AngelisINFRAFRONTIER GmbH, Neuherberg, Germany.ORCID 0000-0002-7898-2353
George KolliasBiomedical Sciences Research Center "Alexander Fleming", Athens, Greece.ORCID 0000-0003-1867-3150
Dimitris L KontoyiannisBiomedical Sciences Research Center "Alexander Fleming", Athens, Greece.ORCID 0000-0003-4682-9490
Bernard MalissenCentre d'Immunophénomique (CIPHE), Aix Marseille Université, INSERM, CNRS, CELPHEDIA, PHENOMIN, Marseille, France.ORCID 0000-0003-1340-9342
Colin McKerlieThe Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-2232-0967
Radislav SedláčekCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.ORCID 0000-0002-3352-392X
Sara E WellsMRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire, UK.ORCID 0000-0002-0572-0600
Ana ZarubicaCentre d'Immunophénomique (CIPHE), Aix Marseille Université, INSERM, CNRS, CELPHEDIA, PHENOMIN, Marseille, France.ORCID 0000-0001-5488-4137
Jan RozmanCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic. jan.rozman@img.cas.cz.ORCID 0000-0002-8035-8904
Tania SorgUniversite de Strasbourg, CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de La Souris, Illkirch, France. tsorg@igbmc.fr.ORCID 0000-0001-6974-4735

Funding

Medical Research Council MC_U142684172Medical Research Council MC_UP_1502/1
6 · The paper itself

Abstract

Improving reproducibility and replicability in preclinical research is a widely discussed and pertinent topic, especially regarding ethical responsibility in animal research. INFRAFRONTIER, the European Research Infrastructure for the generation, phenotyping, archiving, and distribution of model mammalian genomes, is addressing this issue by developing internal quality principles for its different service areas, that provides a quality framework for its operational activities. This article introduces the INFRAFRONTIER Quality Principles in Systemic Phenotyping of genetically altered mouse models. A total of 11 key principles are included, ranging from general requirements for compliance with guidelines on animal testing, to the need for well-trained personnel and more specific standards such as the exchange of reference lines. Recently established requirements such as the provision of FAIR (Findable, Accessible, Interoperable, Reusable) data are also addressed. For each quality principle, we have outlined the specific context, requirements, further recommendations, and key references.

Indexed as

GenomeMammalsAnimalsDisease Models, AnimalMiceReproducibility of Results

Identifiers

PMID34328547
PMCPMC8913563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.