Evidence map›Paper›PMID 34328514›Full record

ArticleDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete2021

[Treatment of atopic dermatitis with dupilumab : A retrospective cohort analysis from dermatological practice].

Sigbert Jahn, Julia Föhr, Evangelia Diamanti, Matthias Herbst

Abstract read
In one paragraph

Article in Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sigbert JahnDermatologische Praxis Dr. Herbst & Kollegen, Rheinstr. 7, 64283, Darmstadt, Deutschland. sigbertjahn@hotmail.com.
Julia FöhrDermatologische Praxis Dr. Herbst & Kollegen, Rheinstr. 7, 64283, Darmstadt, Deutschland.
Evangelia DiamantiDermatologische Praxis Dr. Herbst & Kollegen, Rheinstr. 7, 64283, Darmstadt, Deutschland.
Matthias HerbstDermatologische Praxis Dr. Herbst & Kollegen, Rheinstr. 7, 64283, Darmstadt, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the results of a retrospective data analysis of a practice cohort of 44 patients with atopic dermatitis treated with the IL-4/13 receptor antibody dupilumab for up to 3 years. Patients were followed up over a period of 21 months during specialized consultation hours named Immunodermatology, which was established to guarantee comprehensive documentation. The patient's characteristics regarding age and sex distribution, severity and duration of disease were comparable with the patient collectives in large, pivotal studies. The therapeutic efficiency however was high (percentage of patients with EASI50, -75, -90 after 16 weeks: 94, 84, 60%, respectively) and long lasting (86% EASI90 after 52 weeks on therapy) under everyday conditions in the clinical setting. Approximately half of the patients had facial skin or eye involvement either in their history or at the start of treatment. This group of patients proved to need more and intense care because facial dermatitis and periocular dermatitis, which often involved conjunctivitis, took longer to heal, relapses occurred, and an additional topical treatment was often required. We did not observe any severe side effects during the 48 patient-years analyzed in this study. Dupilumab proved to be a safe and efficient treatment for atopic dermatitis in dermatological practice.

Indexed as

Dermatitis, AtopicAntibodies, Monoclonal, HumanizedCohort StudiesHumansRetrospective StudiesSeverity of Illness IndexTreatment OutcomeAntibodies, Monoclonal, HumanizeddupilumabFacial dermatitisImmunodermatologyImmunomodulationInterleukin-4/13 blockadePeriocular dermatitis

Identifiers

PMID34328514
PMCPMC8323538

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.