Evidence map›Paper›PMID 34328378›Full record

ArticleClinical toxicology (Philadelphia, Pa.)2022

Development of sodium tetrathionate as a cyanide and methanethiol antidote.

Adriano Chan, Jangwoen Lee, Subrata Bhadra, Nesta Bortey-Sam, Tara B Hendry-Hofer, Vikhyat S Bebarta, Sari B Mahon, Matthew Brenner, Brian Logue, Renate B Pilz and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical toxicology (Philadelphia, Pa.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Adriano ChanDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Jangwoen LeeBeckman Laser Institute, University of California, Irvine, Irvine, CA, USA.
Subrata BhadraDepartment of Chemistry and Biochemistry, South Dakota State University, Brookings, SD, USA.
Nesta Bortey-SamGraduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Tara B Hendry-HoferDepartment of Emergency Medicine, University of Colorado, Aurora, CO, USA.
Vikhyat S BebartaDepartment of Emergency Medicine, University of Colorado, Aurora, CO, USA.ORCID 0000-0001-8816-1199
Sari B MahonBeckman Laser Institute, University of California, Irvine, Irvine, CA, USA.
Matthew BrennerBeckman Laser Institute, University of California, Irvine, Irvine, CA, USA.
Brian LogueDepartment of Chemistry and Biochemistry, South Dakota State University, Brookings, SD, USA.
Renate B PilzDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Gerry R BossDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
University of California, Irvine · USUniversity of California San Diego · USSouth Dakota State University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Pittsburgh · US

Funding

Sodium Tetrathionate as a Cyanide AntidoteU01NS105057 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2017 to 2019
$2.0M
NINDS NIH HHS U01 NS105057
6 · The paper itself

Abstract

contextHydrogen cyanide and methanethiol are two toxic gases that inhibit mitochondrial cytochrome

resultsWe show that tetrathionate, unlike thiosulfate, reacts directly with cyanide

conclusionWe conclude that tetrathionate has the potential to be an effective antidote against cyanide and methanethiol poisoning.

Indexed as

AntidotesTetrathionic AcidAnimalsCHO CellsCricetinaeCricetulusCyanidesHumansMiceRabbitsRatsSulfhydryl CompoundsThiosulfatesAntidotesCyanidesmethylmercaptanSulfhydryl CompoundsTetrathionic AcidThiosulfatesCyanidemethanethiolmicerabbitssodium tetrathionatesodium thiosulfate

Identifiers

PMID34328378
PMCPMC8800944
OpenAlexW3184538590

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.