ArticleAmerican journal of physiology. Heart and circulatory physiology2021
Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood.
Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07244809 (Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Resistance exercise lowers blood pressure and improves vascular endothelial function in individuals with elevated blood pressure or stage-1 hypertension.American journal of physiology. Heart and circulatory physiology · 2024Trial
- Progressive iso-inertial resistance exercise promotes more favorable cardiovascular adaptations than traditional resistance exercise in young adults.American journal of physiology. Heart and circulatory physiology · 2024Trial
- Progressive exercise training improves cardiovascular psychophysiological outcomes in young adult women with a history of adverse childhood experiences.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Redox dysregulation, inflammation and mental health in adults with high risk of childhood maltreatment.European child & adolescent psychiatry · 2026Article
- Stress Trajectory and Hypertension 2 to 7 Years After Delivery: A nuMoM2b-HHS Study.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse.Molecular psychiatry · 2026Article
- Multifaceted role of nitric oxide in vascular dementia.Medical gas research · 2025Review
- Early life adversity and adult attention-deficit/hyperactivity disorder (ADHD): Pathways to persistence and adult susceptibility.Neuroscience and biobehavioral reviews · 2025Review
- Childhood Adversity and Cardiovascular Disease; Current Knowledge and Future Directions.Current cardiology reports · 2025Review
- Oxidative Stress and Endothelial Dysfunction: The Pathogenesis of Pediatric Hypertension.International journal of molecular sciences · 2025Review
- Emerging cardiovascular risk factors in childhood and adolescence: a narrative review.European journal of pediatrics · 2025Review
- Interactions of chronic stress exposure and stress appraisal on vascular endothelial function among young adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Cardiovascular Consequences of Posttraumatic Stress Disorder: Exaggerated Vasoconstrictor Responsiveness to Personalized Trauma Recall.Biological psychiatry · 2024Article
- Impact of Adverse Childhood Experiences in Young Adults and Adults: A Systematic Literature Review.Pediatric reports · 2024Review
- Exercise to Prevent Accelerated Vascular Aging in People Living With HIV.Circulation research · 2024Review
- No Mediation Effect of Telomere Length or Mitochondrial DNA Copy Number on the Association Between Adverse Childhood Experiences (ACEs) and Central Arterial Stiffness.Journal of the American Heart Association · 2022Article
- Targeting SIRT1 Rescues Age- and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels.Circulation research · 2022Article
- The Link Between Childhood Adversity and Cardiovascular Disease Risk: Role of Cerebral and Systemic Vasculature.Function (Oxford, England) · 2022Article
- Developmental toxicant exposures and sex-specific effects on epigenetic programming and cardiovascular health across generations.Environmental epigenetics · 2022Review
- Preconception stress exposure from childhood to adolescence and birth outcomes: The impact of stress type, severity and consistency.Frontiers in reproductive health · 2022Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Adverse childhood experiences (ACEs) are psychosocial stressors that occur during sensitive developmental windows and are associated with increased lifetime cardiovascular disease (CVD) risk in a dose-dependent manner. Vascular endothelial dysfunction is a pathophysiological mechanism that promotes hypertension and CVD and may be a mechanism by which ACEs contribute to lifetime CVD risk. We examined whether exposure to ACEs is associated with reduced vascular endothelial function (VEF) in otherwise healthy, young adult women (20.7 ± 3 yr) with (ACE
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.