Evidence map›Paper›PMID 34328338›Full record

ArticleMolecular pharmaceutics2021

Development of a

Lingzhou Zhao, Changcun Liu, Yan Xing, Jin He, Jim O'Doherty, Wenhua Huang, Jinhua Zhao

Abstract readClinical Trial, Phase I
PubMed Publisher
In one paragraph

Article in Molecular pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Detection of HER2 expression usingBreast cancer research : BCR · 2024
    Trial
  2. Current and future perspectives of molecular breast imaging with [European journal of nuclear medicine and molecular imaging · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Preclinical Evaluation of a Novel High-Affinity Radioligand [International journal of molecular sciences · 2023
    Article
  11. Review
  12. Monte Carlo-derivedMedical physics · 2023
    Article
  13. Article
  14. Review
  15. Review
  16. European journal of nuclear medicine and molecular imaging · 2023
    Article
  17. Review
  18. International journal of nanomedicine · 2023
    Article
  19. Article
  20. Phase I clinical evaluation ofTheranostics · 2023
    Article
4 · The record

Corrections and comments

  • Commented on by
    2023
5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Lingzhou ZhaoDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China.
Changcun LiuDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China.
Yan XingDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China.
Jin HeDepartment of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Jim O'DohertySiemens Healthineers, Malvern, Pennsylvania 19355, United States.
Wenhua HuangNanomab Technology Limited, Shanghai 200080, China.
Jinhua ZhaoDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China.ORCID 0000-0002-8867-7985
Shanghai Jiao Tong University · CNSiemens Healthcare (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate determination of human epidermal growth factor receptor 2 (HER2) expression is essential for HER2-targeted therapy in patients with cancer. HER2 expression in a complex environment, such as in a heterogeneous tumor, makes the precise assessment of the HER2 status difficult using current methods. In this study, we developed a novel

Indexed as

AdultBreast NeoplasmsErb-b2 Receptor Tyrosine KinasesFemaleHumansMiddle AgedMolecular ImagingRadiopharmaceuticalsSingle-Domain AntibodiesSingle Photon Emission Computed Tomography Computed TomographyTechnetiumTissue DistributionERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesRadiopharmaceuticalsSingle-Domain AntibodiesTechnetiumTechnetium-99breast cancerHER2 imagingsingle-domain antibodySPECT/CT

Identifiers

PMID34328338
OpenAlexW3183150027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.