Evidence map›Paper›PMID 34327875›Full record

ArticlePharmacology research & perspectives2021

Human-induced pluripotent stem cell-derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs.

Jorge Gomez-Galeno, Karl Okolotowicz, Mark Johnson, Wesley L McKeithan, Mark Mercola, John R Cashman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jorge Gomez-GalenoHuman BioMolecular Research Institute, San Diego, CA, USA.
Karl OkolotowiczDepartment of Medicine, Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Mark JohnsonHuman BioMolecular Research Institute, San Diego, CA, USA.
Wesley L McKeithanDepartment of Medicine, Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Mark MercolaDepartment of Medicine, Cardiovascular Institute, Stanford University, Stanford, CA, USA.
John R CashmanHuman BioMolecular Research Institute, San Diego, CA, USA.ORCID 0000-0002-8628-9129
Cardiovascular Institute of the South · USHuman BioMolecular Research Institute · US

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2M
NCI NIH HHS P30 CA030199
6 · The paper itself

Abstract

Prolongation of the cardiac action potential (AP) and early after depolarizations (EADs) are electrical anomalies of cardiomyocytes that can lead to lethal arrhythmias and are potential liabilities for existing drugs and drug candidates in development. For example, long QT syndrome-3 (LQTS3) is caused by mutations in the Na

Indexed as

AnimalsBehavior, AnimalCells, CulturedFemaleHumansInduced Pluripotent Stem CellsLiverLong QT SyndromeMaleMexiletineMiceMice, Inbred BALB CMyocytes, CardiacRatsRats, Sprague-DawleySeizuresMexiletinearrhythmiasdeuterated phenyl mexiletineshuman-induced pluripotent stem cells-derived cardiomyocytesmetabolismmexiletinephenyl mexiletineQT prolongation

Identifiers

PMID34327875
PMCPMC8322572
OpenAlexW3183972724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.