Evidence map›Paper›PMID 34327571›Full record

ArticleEuropean journal of nutrition2022

Association of dietary sulfur amino acid intake with mortality from diabetes and other causes.

Zhen Dong, Xiang Gao, Vernon M Chinchilli, Raghu Sinha, Joshua Muscat, Renate Winkels, John P Richie

Abstract read
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In one paragraph

Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Methionine restriction and mimetics to ameliorate human aging and disease.Trends in endocrinology and metabolism: TEM · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhen DongDepartment of Public Health Sciences, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, 500 University Drive, Mail Code CH69, Hershey, PA, 17033, USA.
Xiang GaoDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.
Vernon M ChinchilliDepartment of Public Health Sciences, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, 500 University Drive, Mail Code CH69, Hershey, PA, 17033, USA.
Raghu SinhaDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Joshua MuscatDepartment of Public Health Sciences, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, 500 University Drive, Mail Code CH69, Hershey, PA, 17033, USA.
Renate WinkelsDepartment of Public Health Sciences, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, 500 University Drive, Mail Code CH69, Hershey, PA, 17033, USA.
John P RichieDepartment of Public Health Sciences, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, 500 University Drive, Mail Code CH69, Hershey, PA, 17033, USA. jrichie@pennstatehealth.psu.edu.ORCID http://orcid.org/0000-0001-8239-2850

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSulfur amino acid (SAA) consumption in Western countries is far greater than recommended levels. In preclinical studies, reduced SAA intake enhanced longevity and reduced risk for numerous chronic diseases. The current objective was to examine for associations between the intake of total SAA, including methionine (Met) and cysteine (Cys), and all-cause and disease-specific mortality US adults.

methodsThis prospective analysis included 15,083 US adult participants (mean age = 46.7 years) from the Third National Examination and Nutritional Health Survey (NHANES III, 1988-1994) with available mortality status (National Death Registry, 1988-2011). Dietary SAA intake was obtained from 24-h recall data. Associations between quintile (Q) of SAA intake (expressed as absolute intake or protein density) and mortality were assessed using Cox proportional hazard models and expressed as hazard ratio (HR).

resultsDuring follow-up (mean = 16.9 years), 4636 deaths occurred. After multivariable adjustment (including demographics and traditional risk factors, such as fat and other micronutrients intake), diabetes-caused mortality rates were nearly threefold higher in the highest compared to lowest SAA intake quintiles [HR

conclusionResults suggest that high-SAA diets are associated with increased risk for diabetes mortality and that lowering intake towards to Recommended Dietary Allowance levels could lead to reductions in lifetime risk.

Indexed as

Amino Acids, SulfurDiabetes MellitusAdultDietEatingHumansMiddle AgedNutrition SurveysAmino Acids, SulfurCysteineDiabetesMethionineSulfur amino acid restrictionSulfur amino acids

Identifiers

PMID34327571

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.