Evidence map›Paper›PMID 34327516›Full record

ArticleMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention2020

Disentangled Intensive Triplet Autoencoder for Infant Functional Connectome Fingerprinting.

Dan Hu, Fan Wang, Han Zhang, Zhengwang Wu, Li Wang, Weili Lin, Gang Li, Dinggang Shen

Abstract read
In one paragraph

Article in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. INDIVIDUALIZED TRAJECTORY PREDICTION OF EARLY DEVELOPING FUNCTIONAL CONNECTIVITY.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025
    Article
  3. Longitudinally Consistent Individualized Prediction of Infant Cortical Morphological Development.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2024
    Article
  4. Disentangled Hybrid Transformer for Identification of Infants with Prenatal Drug Exposure.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2024
    Article
  5. Multi-task Joint Prediction of Infant Cortical Morphological and Cognitive Development.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023
    Article
  6. Longitudinal Infant Functional Connectivity Prediction via Conditional Intensive Triplet Network.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2022
    Article
  7. Reference-Relation Guided Autoencoder with Deep CCA Restriction for Awake-to-Sleep Brain Functional Connectome Prediction.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dan HuDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Fan WangDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Han ZhangDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Zhengwang WuDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Li WangDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Weili LinDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Gang LiDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Dinggang ShenDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Funding

UNC/UMN Baby Connectome ProjectU01MH110274 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELISON, JED THOMAS, GILMORE, JOHN HORACE · 2016 to 2019
$4.5M
Infant Brain and Behavioral Signatures of Later Emerging Risk for PsychopathologyR01MH104324 · NIMH · UNIVERSITY OF MINNESOTA · PI ELISON, JED THOMAS · 2014 to 2018
$2.6M
Continued Development of Infant Brain Analysis ToolsR01MH117943 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG, WANG, LI · 2018 to 2022
$2.3M
Parcellating Infant Cerebral Cortex based on Developmental Patterns of Multimodal MRIR01MH116225 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG · 2018 to 2022
$1.9M
Volume-based Analysis of 6-month Infant Brain MRI for Autism Biomarker Identification and Early DiagnosisK01MH109773 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WANG, LI · 2017 to 2020
$571k
NIMH NIH HHS K01 MH109773NIMH NIH HHS R01 MH104324NIMH NIH HHS R01 MH116225NIMH NIH HHS R01 MH117943NIMH NIH HHS U01 MH110274
6 · The paper itself

Abstract

Functional connectome "fingerprint" is a highly characterized brain pattern that distinguishes one individual from others. Although its existence has been demonstrated in adults, an unanswered but fundamental question is whether such individualized pattern emerges since infancy. This problem is barely investigated despites its importance in identifying the origin of the intrinsic connectome patterns that mirror distinct behavioral phenotypes. However, addressing this knowledge gap is challenging because the conventional methods are only applicable to developed brains with subtle longitudinal changes and typically fail on the dramatically developing infant brains. To tackle this challenge, we invent a novel model, namely, disentangled intensive triplet autoencoder (DI-TAE). First, we introduce the triplet autoencoder to embed the original connectivity into a latent space with higher discriminative capability among infant individuals. Then, a disentanglement strategy is proposed to separate the latent variables into identity-code, age-code, and noise-code, which not only restrains the interference from age-related developmental variance, but also captures the identity-related invariance. Next, a cross-reconstruction loss and an intensive triplet loss are designed to guarantee the effectiveness of the disentanglement and enhance the inter-subject dissimilarity for better discrimination. Finally, a variance-guided bootstrap aggregating is developed for DI-TAE to further improve the performance of identification. DI-TAE is validated on three longitudinal resting-state fMRI datasets with 394 infant scans aged 16 to 874 days. Our proposed model outperforms other state-of-the-art methods by increasing the identification rate by more than 50%, and for the first time suggests the plausible existence of brain functional connectome "fingerprint" since early infancy.

Indexed as

Infant Functional ConnectomeRs-fMRITriplet Autoencoder

Identifiers

PMID34327516
PMCPMC8318317

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.