Evidence map›Paper›PMID 34327406›Full record

ArticleThe Lancet regional health. Western Pacific2021

Detachable string magnetically controlled capsule endoscopy for detecting high-risk varices in compensated advanced chronic liver disease (CHESS1801): A prospective multicenter study.

Shuai Wang, Yifei Huang, Weiling Hu, Hua Mao, Mark Edward McAlindon, Yanna Liu, Li Yang, Chunqing Zhang, Ming Xu, Chaohui He and 42 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet regional health. Western Pacific, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03749954 (Detachable String Magnetically Controlled Capsule Endoscopy for Detecting High-risk Varices in Compensated Advanced Chronic Liver Disease), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03749954 unknown statusnot on this map

Detachable String Magnetically Controlled Capsule Endoscopy for Detecting High-risk Varices in Compensated Advanced Chronic Liver Disease (CHESS1801): A Prospective Multicenter Study

TypeobservationalSponsorNanfang Hospital, Southern Medical UniversityRan2018 to 2022Enrolled105ConditionsCompensated Cirrhosis, Gastroesophageal Varices BleedingArmsDetachable string magnetically controlled capsule endoscopy
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Prevention of Gastric Cancer.Medicina (Kaunas, Lithuania) · 2026
    Review
  5. Article
  6. Review
  7. New Approaches to Screening for Barrett Esophagus.Gastroenterology & hepatology · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Endoscopic Ruler for varix size measurement: A multicenter pilot study.World journal of gastrointestinal endoscopy · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. [Current status and prospects of clinical research on portal hypertension in China].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021
    Article
  18. A community of portal hypertension.Hepatology international · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors at 15 institutions in 3 countries.

Shuai WangCHESS Center, Department of Liver Diseases, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Yifei HuangCHESS Center, Institute of Portal Hypertension, The First Hospital of Lanzhou University, Lanzhou, China.
Weiling HuDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Medical School; Institute of Gastroenterology, Zhejiang University, Hangzhou, China.
Hua MaoDepartment of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Mark Edward McAlindonAcademic Department of Gastroenterology and Hepatology, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.
Yanna LiuCHESS Center, Institute of Portal Hypertension, The First Hospital of Lanzhou University, Lanzhou, China.
Li YangDivision of Gastroenterology and Hepatology, Digestive Disease Institute, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Chunqing ZhangDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Ming XuDepartment of Gastroenterology, Guangdong Second Provincial General Hospital, Guangzhou, China.
Chaohui HeDepartment of Gastroenterology, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, China.
Tong DangDepartment of Gastroenterology, The Second Affiliated Hospital of Baotou Medical College, Baotou, China.
Bin WuDepartment of Gastroenterology, Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Engineering and Technology Research Center of Digestive Endoscopy, Guangzhou, China.
Dong JiCHESS Center, Department of Liver Diseases, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Liting ZhangDepartment of Hepatology, The First Hospital of Lanzhou University, Lanzhou, China.
Xiaorong MaoDepartment of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou, China.
Lei ZhangDepartment of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China.
Chuan LiuCHESS Center, Institute of Portal Hypertension, The First Hospital of Lanzhou University, Lanzhou, China.
Dan XuCHESS Center, Institute of Portal Hypertension, The First Hospital of Lanzhou University, Lanzhou, China.
Yasong LiDepartment of Liver Diseases, the Seventh Medical Center, Chinese PLA General Hospital, Beijing, China.
Guoan LiDepartment of Liver Diseases, the Seventh Medical Center, Chinese PLA General Hospital, Beijing, China.
Juqiang HanDepartment of Liver Diseases, the Seventh Medical Center, Chinese PLA General Hospital, Beijing, China.
Fangfang LvDepartment of Infectious Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Xiao LiangDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Shaoqin JinDepartment of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Shaoheng ZhangDepartment of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Foong Way David TaiAcademic Department of Gastroenterology and Hepatology, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.
Qing XuDivision of Gastroenterology and Hepatology, Digestive Disease Institute, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Changqing YangDivision of Gastroenterology and Hepatology, Digestive Disease Institute, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Guangchuan WangDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Lifen WangDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Bo LiDepartment of Gastroenterology, Guangdong Second Provincial General Hospital, Guangzhou, China.
Haiyun YangDepartment of Gastroenterology, Guangdong Second Provincial General Hospital, Guangzhou, China.
Ping XieDepartment of Gastroenterology, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, China.
Lulin DengDepartment of Gastroenterology, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, China.
Limei RenDepartment of Gastroenterology, The Second Affiliated Hospital of Baotou Medical College, Baotou, China.
Zhiheng ChangDepartment of Gastroenterology, The Second Affiliated Hospital of Baotou Medical College, Baotou, China.
Xing WangDepartment of Gastroenterology, Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Engineering and Technology Research Center of Digestive Endoscopy, Guangzhou, China.
Shan WangDepartment of Hepatology, The First Hospital of Lanzhou University, Lanzhou, China.
Xiaoqin GaoDepartment of Hepatology, The First Hospital of Lanzhou University, Lanzhou, China.
Junfeng LiDepartment of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou, China.
Longdong ZhuDepartment of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou, China.
Fangzhao WangDepartment of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China.
Lingen ZhangDepartment of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China.
Guo ZhangDepartment of Gastroenterology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Xi JiangNational Clinical Research Center for Digestive Diseases, Department of Gastroenterology, Changhai Hospital, Shanghai, China.
Jun PanNational Clinical Research Center for Digestive Diseases, Department of Gastroenterology, Changhai Hospital, Shanghai, China.
Wenbo MengThe First Hospital of Lanzhou University, Lanzhou, China.
Xun LiThe First Hospital of Lanzhou University, Lanzhou, China.
Jinlin HouDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xavier DraySorbonne University, Centre for Digestive Endoscopy, Saint Antoine Hospital, APHP, Paris, France.
Zhuan LiaoNational Clinical Research Center for Digestive Diseases, Department of Gastroenterology, Changhai Hospital, Shanghai, China.
Xiaolong QiCHESS Center, Institute of Portal Hypertension, The First Hospital of Lanzhou University, Lanzhou, China.
First Hospital of Lanzhou University · CNChinese PLA General Hospital · CNZhujiang Hospital · CNBaotou Medical College · CNGuangdong Provincial People's Hospital · CNSecond Military Medical University · CNShandong Provincial Hospital · CNSir Run Run Shaw Hospital · CNTongji University · CNZunyi Medical University · CNSheffield Teaching Hospitals NHS Foundation Trust · GBSun Yat-sen University · CNNanfang Hospital · CNSorbonne Université · FRThe People's Hospital of Guangxi Zhuang Autonomous Region · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastroesophageal varices is a serious complication of compensated advanced chronic liver disease (cACLD). Primary prophylaxis to reduce the risk of variceal hemorrhage is recommended if high-risk varices (HRV) are detected. We performed this study to compare the accuracy, patients' satisfaction and safety of detection of HRV by detachable string magnetically controlled capsule endoscopy (DS-MCCE) with esophagogastroduodenoscopy (EGD) as the reference.

methodsWe prospectively recruited participants with cACLD from 12 university hospitals (11 in China and one in the United Kingdom) between November 2018 and December 2019 (ClinicalTrials.gov, NCT03749954). All participants underwent DS-MCCE, followed by EGD within a week in a blinded fashion. Following endoscopy, and on the same day, participants were asked to fill in a satisfaction questionnaire regarding their experience.

findingsA total of 105 eligible participants were enrolled. With EGD as the reference standard, the concordance index, sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio of DS-MCCE in diagnosis of HRV were 0•90 (95% confidence interval [CI]: 0•83-0•95), 92% (95% CI: 78-98%), 88% (95% CI: 78-95%), 80% (95% CI: 70-92%), 95% (95% CI: 90-100%), 7•91 (95% CI: 4•10-15•30), and 0•09 (95% CI: 0•03-0•30), respectively. The kappa score of 0•78 (95% CI: 0•65-0•90) suggested substantial agreement between DS-MCCE and EGD. Moreover, in participants undergoing EGD without sedation, the satisfaction of DS-MCCE was significantly better than that of EGD (

interpretationDS-MCCE is an accurate alternative to EGD for detecting HRV in cACLD, which is safe and associated with better satisfaction.

fundingA full list of funding can be found in the Funding Support section.

Indexed as

Clinical trialEsophagogastroduodenoscopyGastroesophageal varicesPortal hypertensionProspective

Identifiers

PMID34327406
PMCPMC8315440
OpenAlexW3112821433

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.