Evidence map›Paper›PMID 34327311›Full record

ArticleACS applied bio materials2020

Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium.

Da Sun, Rebecca M Schur, Avery E Sears, Song-Qi Gao, Wenyu Sun, Amirreza Naderi, Timothy Kern, Krzysztof Palczewski, Zheng-Rong Lu

Open access · greenAbstract read
In one paragraph

Article in ACS applied bio materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Successful large gene augmentation of USH2A with non-viral episomal vectors.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Effective gene therapy of Stargardt disease with PEG-ECO/Molecular therapy. Nucleic acids · 2022
    Article
  11. Review
  12. Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Da SunDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
Rebecca M SchurDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
Avery E SearsDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH 44106.
Song-Qi GaoDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
Wenyu SunDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
Amirreza NaderiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
Timothy KernDepartment of Ophthalmology, University of California Irvine, Irvine, CA 92697-7600.
Krzysztof PalczewskiDepartment of Ophthalmology, University of California Irvine, Irvine, CA 92697-7600.
Zheng-Rong LuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0001-8185-9519
Case Western Reserve University · US

Funding

Novel therapies to inhibit Diabetic RetinopathyR24EY024864 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KERN, TIMOTHY S · 2015 to 2019
$8.1M
Use of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9M
NEI NIH HHS R24 EY024864NEI NIH HHS R24 EY027283
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID34327311
PMCPMC8317636
OpenAlexW3014800882

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.