Evidence map›Paper›PMID 34327309›Full record

ArticleACS applied bio materials2020

On-demand and tunable dual wavelength release of antibody using light-responsive hydrogels.

Paige J LeValley, Bryan P Sutherland, Jennifer Jaje, Sandra Gibbs, Mark Jones, Rikhav Gala, Christopher J Kloxin, Kristi L Kiick, April M Kloxin

Open access · greenAbstract read
In one paragraph

Article in ACS applied bio materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. BiRSC advances · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Smart Hydrogels for Advanced Drug Delivery Systems.International journal of molecular sciences · 2022
    Review
  10. Light-Sensitive Phenacyl Crosslinked Dextran Hydrogels for Controlled Delivery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  11. Light responsive hydrogels for controlled drug delivery.Frontiers in bioengineering and biotechnology · 2022
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Paige J LeValleyDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, United States.
Bryan P SutherlandDepartment of Material Science and Engineering, University of Delaware, Newark, DE, United States.
Jennifer JajeFraunhofer USA Center for Molecular Biotechnology (CMB), Newark, DE, United States.
Sandra GibbsFraunhofer USA Center for Molecular Biotechnology (CMB), Newark, DE, United States.
Mark JonesFraunhofer USA Center for Molecular Biotechnology (CMB), Newark, DE, United States.
Rikhav GalaFraunhofer USA Center for Molecular Biotechnology (CMB), Newark, DE, United States.
Christopher J KloxinDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, United States.
Kristi L KiickDepartment of Material Science and Engineering, University of Delaware, Newark, DE, United States.
April M KloxinDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, United States.
University of Delaware · USFraunhofer USA Center for Molecular Biotechnology · US

Funding

This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8M
Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI PATEL, SANDEEP · 2014 to 2018
$5.8M
Unraveling fibrosis with dynamic microenvironments and molecular toolsDP2HL152424 · NHLBI · UNIVERSITY OF DELAWARE · PI KLOXIN, APRIL M · 2019 to 2019
$2.4M
NHLBI NIH HHS DP2 HL152424NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P30 GM110758
6 · The paper itself

Abstract

There has been an increased interest in the use of protein therapeutics, especially antibodies, for the treatment of a variety of diseases due to their high specificity to tissues and biological pathways of interest. However, the use of antibodies can be hindered by physical aggregation, degradation, and diffusion when injected

Indexed as

biomaterialsdrug deliverylight chemistryphotolabile linker synthesisphotolabile materialsprotein deliverysynthetic hydrogels

Identifiers

PMID34327309
PMCPMC8315695
OpenAlexW3088820961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.