ArticleOptica2021
High-resolution Fourier light-field microscopy for volumetric multi-color live-cell imaging.
Article in Optica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Fisher-information limits of detector-bandwidth-efficient 3D light-field microscopy.Research square · 2026Article
- Fast 3D dynamic visualization of porcine spermatozoa by using high-resolution wavefront coding light sheet microscopy and machine learning.Scientific reports · 2026Article
- Single-shot extended-depth-of-field fourier light field microscopy enabled by a distorted grating.Biomedical optics express · 2026Article
- Volumetric Single-Molecule Tracking Inside Subcellular Structures.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Volumetric localization microscopy with deep learning.Nature communications · 2025Article
- Lipid nanoparticle-mediated mRNA delivery to CD34Nature biotechnology · 2025Article
- Dual-Channel Event Microscopy for Ultrafast Biological Imaging.bioRxiv : the preprint server for biology · 2025Article
- Volumetric imaging and computation to explore contractile function in zebrafish hearts.Cell reports methods · 2025Article
- Adaptive-learning physics-assisted light-field microscopy enables day-long and millisecond-scale super-resolution imaging of 3D subcellular dynamics.Nature communications · 2025Article
- Fourier Lightfield Multiview Stereoscope for Large Field-of-View 3D Imaging in Microsurgical Settings.Advanced photonics nexus · 2025Article
- Imaging 3D cell cultures with optical microscopy.Nature methods · 2025Review
- Spaceflight alters protein levels and gene expression associated with stress response and metabolic characteristics in human cardiac spheroids.Biomaterials · 2025Article
- Multiscale and recursive unmixing of spatiotemporal rhythms for live-cell and intravital cardiac microscopy.Nature cardiovascular research · 2025Article
- Long-term intravital subcellular imaging with confocal scanning light-field microscopy.Nature biotechnology · 2025Article
- Review
- Wide-field, high-resolution reconstruction in computational multi-aperture miniscope using a Fourier neural network.Optica · 2024Article
- Efficient high-resolution fluorescence projection imaging over an extended depth of field through optical hardware and deep learning optimizations.Biomedical optics express · 2024Article
- Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Light-field flow cytometry for high-resolution, volumetric and multiparametric 3D single-cell analysis.Nature communications · 2024Article
- Fast light-field 3D microscopy with out-of-distribution detection and adaptation through conditional normalizing flows.Biomedical optics express · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Volumetric interrogation of the organization and processes of intracellular organelles and molecules in cellular systems with a high spatiotemporal resolution is essential for understanding cell physiology, development, and pathology. Here, we report high-resolution Fourier light-field microscopy (HR-FLFM) for fast and volumetric live-cell imaging. HR-FLFM transforms conventional cell microscopy and enables exploration of less accessible spatiotemporal-limiting regimes for single-cell studies. The results present a near-diffraction-limited resolution in all three dimensions, a five-fold extended focal depth to several micrometers, and a scanning-free volume acquisition time up to milliseconds. The system demonstrates instrumentation accessibility, low photo damage for continuous observation, and high compatibility with general cell assays. We anticipate HR-FLFM to offer a promising methodological pathway for investigating a wide range of intracellular processes and functions with exquisite spatiotemporal contextual details.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.