Evidence map›Paper›PMID 34327249›Full record

ArticleOpen forum infectious diseases2021

Development and Validation of a Multivariable Prediction Model for Missed HIV Health Care Provider Visits in a Large US Clinical Cohort.

April C Pettit, Aihua Bian, Cassandra O Schember, Peter F Rebeiro, Jeanne C Keruly, Kenneth H Mayer, W Christopher Mathews, Richard D Moore, Heidi M Crane, Elvin Geng and 3 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Emerging from the shadows: Trends in HIV ambulatory care, viral load testing, and viral suppression in a U.S. HIV cohort, 2019-2022: Impact of COVID-19 pandemic.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2024
    Article
  7. Observational
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

April C PettitDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-8832-0866
Aihua BianDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Cassandra O SchemberDivision of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Peter F RebeiroDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jeanne C KerulyDivision of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA.
Kenneth H MayerFenway Health and Harvard Medical School, Boston, Massachusetts, USA.
W Christopher MathewsDepartment of Medicine, University of California San Diego, San Diego, California, USA.
Richard D MooreDivision of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA.
Heidi M CraneDivision of Infectious Diseases, University of Washington School of Medicine, Seattle, Washington, USA.
Elvin GengDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Sonia NapravnikDivision of Infectious Diseases, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Bryan E ShepherdDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Michael J MugaveroDivision of Infectious Diseases, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Judith Tsui · 1988 to 2026
$104.9M
Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Koethe · 2015 to 2026
$27.5M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Johns Hopkins HIV Clinical CohortU01DA036935 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2014 to 2024
$14.9M
Statistical Methods for Ordinal Variables in HIV/AIDS StudiesR01AI093234 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Chun Li, Bryan Earl Shepherd · 2011 to 2026
$4.9M
NCATS NIH HHS TL1 TR002244NCATS NIH HHS UL1 TR000430NIAID NIH HHS K01 AI131895NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI036214NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI060354NIAID NIH HHS P30 AI094189NIAID NIH HHS P30 AI110527NIAID NIH HHS R01 AI093234NIAID NIH HHS R24 AI067039NIDA NIH HHS U01 DA036935NIMH NIH HHS R01 MH113438
6 · The paper itself

Abstract

backgroundIdentifying individuals at high risk of missing HIV care provider visits could support proactive intervention. Previous prediction models for missed visits have not incorporated data beyond the individual level.

methodsWe developed prediction models for missed visits among people with HIV (PWH) with ≥1 follow-up visit in the Center for AIDS Research Network of Integrated Clinical Systems from 2010 to 2016. Individual-level (medical record data and patient-reported outcomes), community-level (American Community Survey), HIV care site-level (standardized clinic leadership survey), and structural-level (HIV criminalization laws, Medicaid expansion, and state AIDS Drug Assistance Program budget) predictors were included. Models were developed using random forests with 10-fold cross-validation; candidate models with the highest area under the curve (AUC) were identified.

resultsData from 382 432 visits among 20 807 PWH followed for a median of 3.8 years were included; the median age was 44 years, 81% were male, 37% were Black, 15% reported injection drug use, and 57% reported male-to-male sexual contact. The highest AUC was 0.76, and the strongest predictors were at the individual level (prior visit adherence, age, CD4+ count) and community level (proportion living in poverty, unemployed, and of Black race). A simplified model, including readily accessible variables available in a web-based calculator, had a slightly lower AUC of .700.

conclusionsPrediction models validated using multilevel data had a similar AUC to previous models developed using only individual-level data. The strongest predictors were individual-level variables, particularly prior visit adherence, though community-level variables were also predictive. Absent additional data, PWH with previous missed visits should be prioritized by interventions to improve visit adherence.

Indexed as

HIVmissed visitsprediction modelrandom forestsretention in care

Identifiers

PMID34327249
PMCPMC8314944

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.