Evidence map›Paper›PMID 34327193›Full record

ArticleFrontiers in bioengineering and biotechnology2021

Human Serum Enhances Biomimicry of Engineered Tissue Models of Bone and Cancer.

Aranzazu Villasante, Samuel T Robinson, Andrew R Cohen, Roberta Lock, X Edward Guo, Gordana Vunjak-Novakovic

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Engineering complexity in human tissue models of cancer.Advanced drug delivery reviews · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Aranzazu VillasanteDepartment of Biomedical Engineering, Columbia University, New York, NY, United States.
Samuel T RobinsonDepartment of Biomedical Engineering, Columbia University, New York, NY, United States.
Andrew R CohenDepartment of Electrical and Computer Engineering, College of Engineering, Drexel University, Philadelphia, PA, United States.
Roberta LockDepartment of Biomedical Engineering, Columbia University, New York, NY, United States.
X Edward GuoDepartment of Biomedical Engineering, Columbia University, New York, NY, United States.
Gordana Vunjak-NovakovicDepartment of Biomedical Engineering, Columbia University, New York, NY, United States.
Columbia University · USDrexel University · USUniversitat de Barcelona · ES

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Tissue Engineering Resource Center: TTDP41EB027062 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gordana Vunjak-Novakovic · 2019 to 2026
$12.6M
NIBIB NIH HHS P41 EB002520NIBIB NIH HHS P41 EB027062
6 · The paper itself

Abstract

For decades, fetal bovine serum (FBS) has been used routinely for culturing many cell types, based on its empirically demonstrated effects on cell growth, and the lack of suitable non-xenogeneic alternatives. The FBS-based culture media do not represent the human physiological conditions, and can compromise biomimicry of preclinical models. To recapitulate

Indexed as

3D cancer models3Rscypridina luciferaseEwing’s sarcomahuman serum

Identifiers

PMID34327193
PMCPMC8313998
OpenAlexW3178839562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.