Evidence map›Paper›PMID 34327153›Full record

ArticleFrontiers in cellular and infection microbiology2021

Uncovering Transcriptional Regulators and Targets of sRNAs Using an Integrative Data-Mining Approach: H-NS-Regulated RseX as a Case Study.

Mia K Mihailovic, Alyssa M Ekdahl, Angela Chen, Abigail N Leistra, Bridget Li, Javier González Martínez, Matthew Law, Cindy Ejindu, Éric Massé, Peter L Freddolino and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. CsrA Shows Selective Regulation of sRNA-mRNA Networks.bioRxiv : the preprint server for biology · 2023
    Article
  8. CsrA selectively modulates sRNA-mRNA regulator outcomes.Frontiers in molecular biosciences · 2023
    Article
  9. Review
  10. Noncoding RNAs: biology and applications-a Keystone Symposia report.Annals of the New York Academy of Sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Mia K MihailovicMcKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, United States.
Alyssa M EkdahlMcKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, United States.
Angela ChenMcKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, United States.
Abigail N LeistraMcKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, United States.
Bridget LiMcKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, United States.
Javier González MartínezMcKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, United States.
Matthew LawMcKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, United States.
Cindy EjinduMcKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, United States.
Éric MasséDepartment of Biochemistry and Functional Genomics, Universitéde Sherbrooke, RNA Group, Sherbrooke, QC, Canada.
Peter L FreddolinoDepartment of Biological Chemistry and Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, United States.
Lydia M ContrerasMcKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, United States.
The University of Texas at Austin · USUniversité de Sherbrooke · CAUniversity of Michigan–Ann Arbor · US

Funding

CIHR
6 · The paper itself

Abstract

Bacterial small RNAs (sRNAs) play a vital role in pathogenesis by enabling rapid, efficient networks of gene attenuation during infection. In recent decades, there has been a surge in the number of proposed and biochemically-confirmed sRNAs in both Gram-positive and Gram-negative pathogens. However, limited homology, network complexity, and condition specificity of sRNA has stunted complete characterization of the activity and regulation of these RNA regulators. To streamline the discovery of the expression of sRNAs, and their post-transcriptional activities, we propose an integrative

Indexed as

RNA, Small UntranslatedData MiningEscherichia coliGene Expression Regulation, BacterialRNA, BacterialRNA, BacterialRNA, Small Untranslatedbacterial small RNAbioinformaticsdata miningpost-transcriptional regulation of gene expressionregulatory RNA networks

Identifiers

PMID34327153
PMCPMC8313858
OpenAlexW3178267892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.