Evidence map›Paper›PMID 34327152›Full record

ReviewFrontiers in cellular and infection microbiology2021

Structural Dynamics and Perspectives of Vitamin B6 Biosynthesis Enzymes in

Angélica Luana C Barra, Najeeb Ullah, Luana G Morão, Carsten Wrenger, Christian Betzel, Alessandro S Nascimento

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Angélica Luana C BarraPólo TerRa, São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.
Najeeb UllahInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University of Hamburg, Hamburg, Germany.
Luana G MorãoPólo TerRa, São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.
Carsten WrengerUnit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Christian BetzelInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University of Hamburg, Hamburg, Germany.
Alessandro S NascimentoPólo TerRa, São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria is still today one of the most concerning diseases, with 219 million infections in 2019, most of them in Sub-Saharan Africa and Latin America, causing approx. 409,000 deaths per year. Despite the tremendous advances in malaria treatment and prevention, there is still no vaccine for this disease yet available and the increasing parasite resistance to already existing drugs is becoming an alarming issue globally. In this context, several potential targets for the development of new drug candidates have been proposed and, among those, the

Indexed as

MalariaPlasmodiumGlutaminaseHumansPlasmodium falciparumVitamin B 6GlutaminaseVitamin B 6malariaPdx1Pdx2Plasmodium falciparumpyridoxal 5-phosphatevitamin B6

Identifiers

PMID34327152
PMCPMC8313854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.