Evidence map›Paper›PMID 34327051›Full record

ArticlePeerJ2021

Detection of genomic regions associated malformations in newborn piglets: a machine-learning approach.

Siroj Bakoev, Aleksei Traspov, Lyubov Getmantseva, Anna Belous, Tatiana Karpushkina, Olga Kostyunina, Alexander Usatov, Tatiana V Tatarinova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Siroj BakoevFederal Research Center for Animal Husbandry named after Academy Member LK. Ernst, Dubrovitsy, Russia.
Aleksei TraspovFederal Research Center for Animal Husbandry named after Academy Member LK. Ernst, Dubrovitsy, Russia.
Lyubov GetmantsevaFederal Research Center for Animal Husbandry named after Academy Member LK. Ernst, Dubrovitsy, Russia.
Anna BelousFederal Research Center for Animal Husbandry named after Academy Member LK. Ernst, Dubrovitsy, Russia.
Tatiana KarpushkinaFederal Research Center for Animal Husbandry named after Academy Member LK. Ernst, Dubrovitsy, Russia.
Olga KostyuninaFederal Research Center for Animal Husbandry named after Academy Member LK. Ernst, Dubrovitsy, Russia.
Alexander UsatovSouth Federal University, Rostov-on-Don, Russia.
Tatiana V TatarinovaDepartment of Biology, University of La Verne, La Verne, CA, United States of America.
Federal Scientific Center for Animal Husbandry named after Academician L.K. Ernst · RUCenter for Strategic Research · RUSiberian Federal University · RUSouthern Federal University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA significant proportion of perinatal losses in pigs occurs due to congenital malformations. The purpose of this study is the identification of genomic loci associated with fetal malformations in piglets.

methodsThe malformations were divided into two groups: associated with limb defects (piglet splay leg) and associated with other congenital anomalies found in newborn piglets. 148 Landrace and 170 Large White piglets were selected for the study. A genome-wide association study based on the gradient boosting machine algorithm was performed to identify markers associated with congenital anomalies and piglet splay leg.

resultsForty-nine SNPs (23 SNPs in Landrace pigs and 26 SNPs in Large White) were associated with congenital anomalies, 22 of which were localized in genes. A total of 156 SNPs (28 SNPs in Landrace; 128 in Large White) were identified for piglet splay leg, of which 79 SNPs were localized in genes. We have demonstrated that the gradient boosting machine algorithm can identify SNPs and their combinations associated with significant selection indicators of studied malformations and productive characteristics. DATA AVAILABILITY: Genotyping and phenotyping data are available at http://www.compubioverne.group/data-and-software/.

Indexed as

AgricultureCongenital malformationsGWASMachine learningPigs

Identifiers

PMID34327051
PMCPMC8310618
OpenAlexW3185864840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.