ArticleApplied sciences (Basel, Switzerland)2021
Interactions between Phase-Separated Liquids and Membrane Surfaces.
Article in Applied sciences (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Non-invasive measurement of biomolecular condensate interfacial tension and bending rigidity.Cell reports methods · 2025Article
- Phase Separation: Orchestrating Biological Adaptations to Environmental Fluctuations.International journal of molecular sciences · 2025Review
- Coupling liquid phases in 3D condensates and 2D membranes: Successes, challenges, and tools.Biophysical journal · 2024Review
- Transcriptional condensates: a blessing or a curse for gene regulation?Communications biology · 2024Review
- Biomolecular condensates modulate membrane lipid packing and hydration.Nature communications · 2023Article
- SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis.PLoS biology · 2023Article
- Protein nanocondensates: the next frontier.Biophysical reviews · 2023Review
- A bending rigidity parameter for stress granule condensates.Science advances · 2023Article
- Membrane reshaping by protein condensates.Biochimica et biophysica acta. Biomembranes · 2023Review
- Microfluidics for multiscale studies of biomolecular condensates.Lab on a chip · 2022Review
- Membrane mediated phase separation of the bacterial nucleoid occlusion protein Noc.Scientific reports · 2022Article
- Coacervation of poly-electrolytes in the presence of lipid bilayers: mutual alteration of structure and morphology.Chemical science · 2022Article
- Protein conformation and biomolecular condensates.Current research in structural biology · 2022Review
- Coupling Bulk Phase Separation of Disordered Proteins to Membrane Domain Formation in Molecular Simulations on a Bespoke Compute Fabric.Membranes · 2021Article
- Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders.Antioxidants (Basel, Switzerland) · 2021Review
- Wetting of phase-separated droplets on plant vacuole membranes leads to a competition between tonoplast budding and nanotube formation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Liquid-liquid phase separation has recently emerged as an important fundamental organizational phenomenon in biological settings. Most studies of biological phase separation have focused on droplets that "condense" from solution above a critical concentration, forming so-called "membraneless organelles" suspended in solution. However, membranes are ubiquitous throughout cells, and many biomolecular condensates interact with membrane surfaces. Such membrane-associated phase-separated systems range from clusters of integral or peripheral membrane proteins in the plane of the membrane to free, spherical droplets wetting membrane surfaces to droplets containing small lipid vesicles. In this review, we consider phase-separated liquids that interact with membrane surfaces and we discuss the consequences of those interactions. The physical properties of distinct liquid phases in contact with bilayers can reshape the membrane, and liquid-liquid phase separation can construct membrane-associated protein structures, modulate their function, and organize collections of lipid vesicles dynamically. We summarize the common phenomena that arise in these systems of liquid phases and membranes.
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