Evidence map›Paper›PMID 34326907›Full record

ArticleThe open pain journal2017

A Mouse Model of Chronic Pancreatitis Induced by an Alcohol and High Fat Diet.

T Clinkinbeard, R H Kline, L P Zhang, S L McIlwrath, J F Watkins, K N Westlund

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The open pain journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

T ClinkinbeardCenter for Gerontology, School of Public Health, University of Kentucky, 725 Rose St., Lexington, KY 40536, USA.
R H KlineDepartment of Physiology, School of Medicine, University of Kentucky, 800 Rose St., Lexington, KY 40536-0298, USA.
L P ZhangDepartment of Physiology, School of Medicine, University of Kentucky, 800 Rose St., Lexington, KY 40536-0298, USA.
S L McIlwrathDepartment of Physiology, School of Medicine, University of Kentucky, 800 Rose St., Lexington, KY 40536-0298, USA.
J F WatkinsCenter for Gerontology, School of Public Health, University of Kentucky, 725 Rose St., Lexington, KY 40536, USA.
K N WestlundDepartment of Physiology, School of Medicine, University of Kentucky, 800 Rose St., Lexington, KY 40536-0298, USA.
University of Kentucky · US

Funding

NEUROGENIC AMPLIFICATION OF PANCREATITIS PAINR01NS039041 · NINDS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI WESTLUND-HIGH, KARIN N. · 2000 to 2014
$4.8M
BLRD VA I01 BX002695NINDS NIH HHS R01 NS039041
6 · The paper itself

Abstract

BACKGROUND/

aimsStudy of acute pancreatitis in chemically-induced rodent models has provided useful data; models of alcoholic chronic pancreatitis have not been available in mice. The aim of the present study was to characterize a mouse model of chronic pancreatitis induced solely with an alcohol and high fat (AHF) diet.

methodsMice were fed a liquid high fat diet containing 6% alcohol as well as a high fat supplement (57% total dietary fat) over a period of five months or as control, normal chow

resultsMice on the AHF diet exhibited mechanical and heat hypersensitivity as well as fibrotic histology indicative of chronic pancreatitis. Low dose, peripherally restricted opiate loperamide attenuated both mechanical and heat hypersensitivity.

conclusionMice fed an alcohol and high fat diet develop histology consistent with chronic pancreatitis as well as opioid sensitive mechanical and heat hypersensitivity.

Indexed as

Behavioral testFibrosisHypersensitivityLoperamideMu opioidNociceptionPainPancreas

Identifiers

PMID34326907
PMCPMC8317824
OpenAlexW2746581262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.