Evidence map›Paper›PMID 34326848›Full record

ArticleFrontiers in immunology2021

Coordination of the Uptake and Metabolism of Amino Acids in

Qingkui Jiang, Lanbo Shi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Qingkui JiangPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers The State University of New Jersey, Newark, NJ, United States.
Lanbo ShiPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers The State University of New Jersey, Newark, NJ, United States.
Rutgers, The State University of New Jersey · US

Funding

The Warburg effect and host immune response in tuberculosisR01AI127844 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI SHI, LANBO, SUBBIAN, SELVAKUMAR · 2017 to 2021
$3.4M
NIAID NIH HHS R01 AI127844
6 · The paper itself

Abstract

Macrophage polarization to the M1-like phenotype, which is critical for the pro-inflammatory and antimicrobial responses of macrophages against intracellular pathogens, is associated with metabolic reprogramming to the Warburg effect and a high output of NO from increased expression of NOS2. However, there is limited understanding about the uptake and metabolism of other amino acids during M1 polarization. Based on functional analysis of a group of upregulated transporters and enzymes involved in the uptake and/or metabolism of amino acids in

Indexed as

Amino AcidsArginineCell PolarityHumansMacrophage ActivationMacrophagesMycobacterium tuberculosisOxidation-ReductionAmino AcidsArginineamino acid transportersarginine metabolismglutaminolysisimmunometabolismM1 polarizationMycobacterium tuberculosisredox homeostasissystem L transporters

Identifiers

PMID34326848
PMCPMC8315098
OpenAlexW3180692306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.