Evidence map›Paper›PMID 34326763›Full record

ArticleCase reports in ophthalmology

Unexpected Etiology in a Case of Bilateral Maculopathy.

Prem Patel, Kaylie Jones, Deborah I Friedman, David G Birch, Rafael L Ufret-Vincenty

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Prem PatelDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, Texas, USA.
Kaylie JonesRetina Foundation of the Southwest, Dallas, Texas, USA.
Deborah I FriedmanDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, Texas, USA.
David G BirchRetina Foundation of the Southwest, Dallas, Texas, USA.
Rafael L Ufret-VincentyDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, Texas, USA.
Southwestern Medical Center · USRetina Foundation of the Southwest · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 74-year-old woman with a history of rheumatoid arthritis using hydroxychloroquine presented with gradually progressive decreased vision in both eyes and was found to have a bilateral maculopathy. Initial genetic testing was negative, and after discussing the low likelihood of her severe findings being secondary to her relatively low hydroxychloroquine exposure, the possibility of an autoimmune retinopathy was entertained. Updated data on the genetic testing reclassified one of her mutations in HGSNAT as pathogenic. This case highlights the value of genetic testing and the need to keep a high index of suspicion even after initial negative results, given the fact that our knowledge of mutations leading to retinal degeneration is constantly evolving.

Indexed as

Bilateral maculopathyGenetic mutationHGSNATHydroxychloroquinePlaquenil

Identifiers

PMID34326763
PMCPMC8299408
OpenAlexW3178409427

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.