Evidence map›Paper›PMID 34326721›Full record

ArticleFrontiers in cellular neuroscience2021

Negative Feedback Role of Astrocytes in Shaping Excitation in Brain Cell Co-cultures.

Elnaz Khezerlou, Neela Prajapati, Mark A DeCoster

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Elnaz KhezerlouDepartment of Biomedical Engineering, Louisiana Tech University, Ruston, LA, United States.
Neela PrajapatiDepartment of Biomedical Engineering, Louisiana Tech University, Ruston, LA, United States.
Mark A DeCosterDepartment of Biomedical Engineering, Louisiana Tech University, Ruston, LA, United States.
Louisiana Tech University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glial cells play an important role in maintaining neuronal homeostasis and may thus influence excitability in epileptogenesis. These cells in the brain have glutamate (Glu) transporters, which remove this neurotransmitter from the extracellular space. Lack of negative (-) feedback makes local neuronal circuits more excitable and potentially contributing to epileptogenic phenomena. In this study, the role of glial cells in providing (-) feedback is shown through different models of brain cells in culture imaged for intracellular calcium concentration [(Ca

Indexed as

astrocyteblood brain barriercalcium imagingexcitotoxicityglutamateneurons

Identifiers

PMID34326721
PMCPMC8313828
OpenAlexW3180205572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.