ArticleFrontiers in neuroscience2021
Heart Rate Variability Changes in Patients With Major Depressive Disorder: Related to Confounding Factors, Not to Symptom Severity?
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Digital phenotype of mood disorders: A conceptual and critical review.Frontiers in psychiatry · 2022Pooled it
- Electrocardiography-derived autonomic profiles in depression and suicide risk with insights from the UK Biobank.Npj mental health research · 2025Article
- Contribution of physiological dynamics in predicting major depressive disorder severity.Psychophysiology · 2025Article
- Advances and Challenges in Depression Marker Research.Neuropsychiatric disease and treatment · 2025Review
- Article
- A rationale for considering heart/brain axis control in neuropsychiatric disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Review
- Screening for Major Depressive Disorder Using a Wearable Ultra-Short-Term HRV Monitor and Signal Quality Indices.Sensors (Basel, Switzerland) · 2023Article
- Digital Phenotyping for Differential Diagnosis of Major Depressive Episode: Narrative Review.JMIR mental health · 2023Review
- Electrophysiological correlates of mindfulness in patients with major depressive disorder.Frontiers in neuroscience · 2022Article
- Association of 20-Year Longitudinal Depressive Symptoms With Left Ventricular Geometry Outcomes in the Coronary Artery Risk Development in Young Adults Study: A Role for Androgens?Psychosomatic medicineArticle
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to assess the electrophysiological and other influencing factors correlating with symptom severity in patients with major depressive disorder (MDD) under three different conditions: baseline, stress exposure, and relaxation following stress exposure.
methodsSymptom severity was assessed using the Beck Depression Inventory (BDI-II) in 89 inpatients (37 women; mean age 51 years) with MDD. Resting heart rate (RHR), heart rate variability (HRV), respiration rate (RR), skin conductance (SC), and skin temperature (ST) were recorded at baseline for 300 s, under stress exposure for 60 s, and under self-induced relaxation for 300 s. Age, nicotine consumption, body mass index, and blood pressure were evaluated as influencing factors.
resultsThe BDI-II mean score was 29.7 points. Disease severity correlated positively with SC elevation under stress exposure and with a higher RR in the relaxed state, but no association was found between HRV and symptom severity. Age and higher blood pressure were both associated with lower HRV and higher RHR.
conclusionThe results indicate that, in patients with MDD, changes in the autonomic nervous system (ANS) are complex; and the assessment of ANS reactivity to stressors is useful. Elevated blood pressure might be underdiagnosed, although it is already relevant in patients with MDD in their early 50s.
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