Evidence map›Paper›PMID 34326715›Full record

ArticleFrontiers in neuroscience2021

Long Non-coding RNA Uc.48+ Small Interfering RNA Alleviates Neuroinflammatory Hyperalgesia in Gp120-Treated Rats via the P2Y12 Receptor.

Lichao Peng, Bing Wu, Liran Shi, Lifang Zou, Lin Li, Runan Yang, Xiumei Xu, Guilin Li, Shuangmei Liu, Chunping Zhang and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain.International journal of molecular sciences · 2022
    Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lichao PengSchool of Life Sciences, Xiamen University, Xiamen, China.
Bing WuNeuropharmacology Laboratory of Physiology Department, Medical School of Nanchang University, Nanchang, China.
Liran ShiNeuropharmacology Laboratory of Physiology Department, Medical School of Nanchang University, Nanchang, China.
Lifang ZouNeuropharmacology Laboratory of Physiology Department, Medical School of Nanchang University, Nanchang, China.
Lin LiNeuropharmacology Laboratory of Physiology Department, Medical School of Nanchang University, Nanchang, China.
Runan YangNeuropharmacology Laboratory of Physiology Department, Medical School of Nanchang University, Nanchang, China.
Xiumei XuNeuropharmacology Laboratory of Physiology Department, Medical School of Nanchang University, Nanchang, China.
Guilin LiNeuropharmacology Laboratory of Physiology Department, Medical School of Nanchang University, Nanchang, China.
Shuangmei LiuNeuropharmacology Laboratory of Physiology Department, Medical School of Nanchang University, Nanchang, China.
Chunping ZhangDepartment of Cell Biology, Medical School of Nanchang University, Nanchang, China.
Shangdong LiangNeuropharmacology Laboratory of Physiology Department, Medical School of Nanchang University, Nanchang, China.
Nanchang University · CNXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human immunodeficiency virus envelope glycoprotein 120 (gp120) leads to hyperalgesia. Long non-coding RNAs are characterized by the lack of a protein-coding sequence and may contribute to the development and maintenance of inflammatory and neuroinflammatory pain. Rats with neuroinflammatory pain were established by gp120 treatment, which is featured by intensified pain behaviors. Long non-coding RNA uc.48+ was increased in the dorsal root ganglia of gp120-treated rats, and small interfering RNA that targets uc.48+ markedly alleviated hyperalgesia in gp120-treated rats. Notably, uc.48+ overexpression increased P2Y12 expression in control rats dorsal root ganglia and induced hyperalgesia. Uc.48+ small interfering RNA inhibited P2Y12 expression in gp120-treated rats. Uc.48+ potentiated P2Y12 receptor functions in the neurons and heterologous cells. Therefore, uc.48+ siRNA treatment reduced the upregulation of P2Y12 expression and function in DRG neurons, and, hence, alleviated hyperalgesia in gp120-treated rats.

Indexed as

dorsal root gangliaHIV gp120-associated neuroinflammatory painlong non-coding RNAP2Y12 receptorsmall interfering RNA

Identifiers

PMID34326715
PMCPMC8315484
OpenAlexW3182171374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.