Evidence map›Paper›PMID 34326699›Full record

ArticleInternational journal of biological sciences2021

Downregulation of m

Jin Wang, Lirong Tan, Beibei Jia, Xiaofan Yu, Ruixin Yao, Nan OUYang, Xueting Yu, Xiyuan Cao, Jian Tong, Tao Chen and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Ubiquitination and NOncology letters · 2026
    Review
  3. METTL3-mediated mJournal of translational medicine · 2026
    Article
  4. Article
  5. Review
  6. The emerging role of mFrontiers in immunology · 2026
    Review
  7. mFrontiers in cell and developmental biology · 2026
    Review
  8. RNA modification systems as therapeutic targets.Nature reviews. Drug discovery · 2026
    Review
  9. mActa pharmaceutica Sinica. B · 2025
    Review
  10. The mMolecular biomedicine · 2025
    Review
  11. AKT and DUBs: a bidirectional relationship.Cellular & molecular biology letters · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. The therapeutic potential of RNA m(6)A in lung cancer.Cell communication and signaling : CCS · 2024
    Review
  16. Downregulation of the mThe Journal of biological chemistry · 2024
    Article
  17. Review
  18. Progression of mCell death discovery · 2024
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jin WangDepartment of Toxicology, School of Public Health, Medicine College, Soochow University, Suzhou, Jiangsu, 215123, China.
Lirong TanDepartment of Toxicology, School of Public Health, Medicine College, Soochow University, Suzhou, Jiangsu, 215123, China.
Beibei JiaDepartment of Toxicology, School of Public Health, Medicine College, Soochow University, Suzhou, Jiangsu, 215123, China.
Xiaofan YuDepartment of Toxicology, School of Public Health, Medicine College, Soochow University, Suzhou, Jiangsu, 215123, China.
Ruixin YaoDepartment of Toxicology, School of Public Health, Medicine College, Soochow University, Suzhou, Jiangsu, 215123, China.
Nan OUYangDepartment of Toxicology, School of Public Health, Medicine College, Soochow University, Suzhou, Jiangsu, 215123, China.
Xueting YuDepartment of Toxicology, School of Public Health, Medicine College, Soochow University, Suzhou, Jiangsu, 215123, China.
Xiyuan CaoDepartment of Toxicology, School of Public Health, Medicine College, Soochow University, Suzhou, Jiangsu, 215123, China.
Jian TongDepartment of Toxicology, School of Public Health, Medicine College, Soochow University, Suzhou, Jiangsu, 215123, China.
Tao ChenDepartment of Toxicology, School of Public Health, Medicine College, Soochow University, Suzhou, Jiangsu, 215123, China.
Rui ChenDepartment of Respiratory Medicine, The Second Affiliated Hospital of Soochow University, Suzhou Jiangsu, 215004, China.
Jianxiang LiDepartment of Toxicology, School of Public Health, Medicine College, Soochow University, Suzhou, Jiangsu, 215123, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is one of the most common types of carcinoma worldwide. Cigarette smoking is considered the leading cause of lung cancer. Aberrant expression of several YT521-B homology (YTH) family proteins has been reported to be closely associated with multiple cancer types. The present study aims to evaluate the function and regulatory mechanisms of the N6-methyladenosine (m

Indexed as

AnimalsCell Line, TumorCell MovementCell ProliferationDeubiquitinating Enzyme CYLDDNA Copy Number VariationsDown-RegulationGene Expression Regulation, NeoplasticHumansLung NeoplasmsMaleMiceMice, Inbred BALB CMice, NudeNF-kappa B p50 SubunitRNA HelicasesCYLD protein, humanDeubiquitinating Enzyme CYLDNF-kappa B p50 SubunitNFKB1 protein, humanRNA HelicasesYTHDC2 protein, humanCYLDlung cancerm6A RNA methylationNF-κB pathwayYTHDC2

Identifiers

PMID34326699
PMCPMC8315025
OpenAlexW3184581643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.