Evidence map›Paper›PMID 34326683›Full record

ArticleInternational journal of biological sciences2021

Soluble Receptor for Advanced Glycation End-products regulates age-associated Cardiac Fibrosis.

Francesco Scavello, Filippo Zeni, Giuseppina Milano, Federica Macrì, Stefania Castiglione, Estella Zuccolo, Alessandro Scopece, Giovanni Pezone, Calogero C Tedesco, Patrizia Nigro and 8 more

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Glycation in the cardiomyocyte.Vitamins and hormones · 2024
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Effects of RAGE Deletion on the Cardiac Transcriptome during Aging.International journal of molecular sciences · 2022
    Article
  16. Review
  17. Article
  18. Epigenetics alternation in lung fibrosis and lung cancer.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Francesco ScavelloUnit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Filippo ZeniUnit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Giuseppina MilanoVascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Federica MacrìUnit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Stefania CastiglioneUnit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Estella ZuccoloUnit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Alessandro ScopeceVascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Giovanni PezoneUnit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Calogero C TedescoUnit of Biostatistics, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Patrizia NigroVascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Genny DeganiDepartment of Biosciences, University of Milan, Milan, Italy.
Elisa GambiniVascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Fabrizio VegliaUnit of Biostatistics, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Laura PopoloDepartment of Biosciences, University of Milan, Milan, Italy.
Giulio PompilioVascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Gualtiero I ColomboUnit of Immunology and Functional Genomics, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Marco E BianchiChromatin Dynamics Unit, San Raffaele University and IRCCS San Raffaele Hospital, Milan, Italy.
Angela RaucciUnit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
Centro Cardiologico Monzino · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial aging increases the cardiovascular risk in the elderly. The Receptor for Advanced Glycation End-products (RAGE) is involved in age-related disorders. The soluble isoform (sRAGE) acts as a scavenger blocking the membrane-bound receptor activation. This study aims at investigating RAGE contribution to age-related cardiac remodeling. We analyzed the cardiac function of three different age groups of female

Indexed as

AgingActinsAnimalsCell LineFemaleFibroblastsFibrosisHumansMiceMice, Inbred C57BLMyocardiumProtein IsoformsReceptor for Advanced Glycation End ProductsTransforming Growth Factor beta1ActinsProtein IsoformsReceptor for Advanced Glycation End ProductsTransforming Growth Factor beta1agingcardiac remodelingfibrosisheart failuresRAGE

Identifiers

PMID34326683
PMCPMC8315019
OpenAlexW3176802471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.