ArticleJournal of experimental pharmacology2021
Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves of
Article in Journal of experimental pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Establishment and translational evaluation of animal models for skin wound healing: a systematic review.Frontiers in physiology · 2026Pooled it
- Ethnomedicinal plants used for immediate care in Nepal: A cross-cultural review.Journal of ethnobiology and ethnomedicine · 2025Review
- Controlled Delivery of Ketoconazole an Antifungal Agent from Uncemented Titanium Using a Layer-by-Layer Technique.ACS omega · 2024Article
- Medicinal Plants Used by Oromo Community in Kofale District, West-Arsi Zone, Oromia Regional State, Ethiopia.Journal of experimental pharmacology · 2024Article
- The wound healing effect of botanicals and pure natural substances used in in vivo models.Inflammopharmacology · 2023Review
- Extracts ofLife (Basel, Switzerland) · 2023Article
- Evaluation of the Antioxidant and Wound Healing Properties of 80% Methanol Extract and Solvent Fractions of the Leaves ofClinical, cosmetic and investigational dermatology · 2023Article
- Article
- Evaluation of Wound-Healing Activity of Hydrogel Extract ofAdvances in pharmacological and pharmaceutical sciences · 2023Article
- Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract and Solvent Fractions of the Leaves ofJournal of experimental pharmacology · 2023Article
- In-vivo Wound Healing and Anti-Inflammatory Activity of the Solvent Fraction ofJournal of experimental pharmacology · 2022Article
- Evaluation of Wound Healing and Anti-Inflammatory Activity of Hydroalcoholic Leaf Extract ofClinical, cosmetic and investigational dermatology · 2022Article
- Evaluation of Wound Healing Activity of 80% Methanol Root Crude Extract and Solvent Fractions ofJournal of experimental pharmacology · 2022Article
- Cubeb (Frontiers in nutrition · 2022Review
- Formulation, Characterization, and Evaluation of Wound Healing Potency of a NovelAvicenna journal of medical biotechnologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMedicinal plants play an important role in treating various diseases.
methodsExtraction was carried out by maceration using 80% methanol and part of the crude extract fractionated with chloroform, ethyl acetate, and aqueous solvents. Simple ointment bases were prepared using hard paraffin, cetostearyl alcohol, white soft paraffin and wool fat according to British Pharmacopoeia. Then, two types of ointment formulations were prepared from the extract, ie, 5% w/w and 10% w/w. Mice and rats were employed for wound healing study and dermal toxicity test, respectively. Wound healing effects were evaluated by percent of wound contraction, period of epithelialization, tensile strength, and histological analysis as parameters in excision, incision, and burn wound models. Finally, the data were expressed as mean ± SEM, and the results were analyzed using one-way ANOVA followed by post hoc Tukey-test.
resultsIn the excision wound model, the 10% w/w crude extract ointment showed significant wound contraction (
conclusionThe crude, aqueous, and ethyl acetate fraction of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.