Evidence map›Paper›PMID 34326639›Full record

ArticleInternational journal of nanomedicine2021

Toxicity in vitro and in Zebrafish Embryonic Development of Gold Nanoparticles Biosynthesized Using

Sofia Machado, Noelia González-Ballesteros, Anabela Gonçalves, Luana Magalhães, Marisa Sárria Pereira de Passos, Maria Carmen Rodríguez-Argüelles, Andreia Castro Gomes

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Biogenesis of Au Nanoparticles from Plant-Derived Metabolites -ACS biomaterials science & engineering · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Antimicrobial and anti-biofilm activity of silver nanoparticles biosynthesized with Cystoseira algae extracts.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Article
  13. Biomedicines · 2023
    Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sofia Machado *Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, Braga, 4710-057, Portugal.
Noelia González-Ballesteros *CINBIO, Departamento de Química Inorgánica, Universidade de Vigo, Vigo, 36310, Spain.
Anabela GonçalvesCentre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, Braga, 4710-057, Portugal.ORCID 0000-0001-8481-3858
Luana MagalhãesCentre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, Braga, 4710-057, Portugal.
Marisa Sárria Pereira de PassosInternational Iberian Nanotechnology Laboratory (INL), Braga, 4715-330, Portugal.
Maria Carmen Rodríguez-ArgüellesCINBIO, Departamento de Química Inorgánica, Universidade de Vigo, Vigo, 36310, Spain.
Andreia Castro GomesCentre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, Braga, 4710-057, Portugal.ORCID 0000-0002-0567-064X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionResearch on gold nanoparticles (AuNPs) occupies a prominent place in the field of biomedicine nowadays, being their putative toxicity and bioactivity areas of major concern. The green synthesis of metallic nanoparticles using extracts from marine organisms allows the avoidance of hazardous production steps while maintaining features of interest, thus enabling the exploitation of their promising bioactivity.

objectiveTo synthesize and characterize AuNPs using, for the first time, macroalga

methodsAlgal aqueous extracts were used for the synthesis of AuNPs, which were characterized using a wide panel of physicochemical techniques and biological assays.

resultsThe characterization by UV-Vis spectroscopy, transmission electron microscopy, Z-potential and infrared spectroscopy confirmed that Au@CT were stable, spherical and polycrystalline, with a mean diameter of 7.6 ± 2.2 nm. The antioxidant capacity of the extract, prior to and after synthesis, was analyzed in vitro, showing that the high antioxidant potential was not lost during the synthesis. Subsequently, in vitro and in vivo toxicity was screened, by comparing two species of the genus

conclusionAu@CT and Au@CB display promising features, desirable for biomedical applications, as wound healing.

Indexed as

Metal NanoparticlesSeaweedAnimalsCell LineEmbryonic DevelopmentGoldGreen Chemistry TechnologyHumansMicePlant ExtractsZebrafishGoldPlant ExtractsbioactivityCystoseira sp.gold nanoparticlesgreen synthesistoxicityzebrafish embryotoxicity test

Identifiers

PMID34326639
PMCPMC8315781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.