Evidence map›Paper›PMID 34326554›Full record

ArticleExperimental mechanics2021

MicroCT Imaging of Heart Valve Tissue in Fluid.

S E Stephens, M Bean, H Surber, N B Ingels, H K Jensen, S Liachenko, J F Wenk, M O Jensen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental mechanics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

S E StephensDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.
M BeanDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.
H SurberDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.
N B IngelsDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.
H K JensenDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.
S LiachenkoDivision of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA.
J F WenkDepartment of Mechanical Engineering, University of Kentucky, Lexington, Kentucky, USA.
M O JensenDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.
University of Arkansas at Fayetteville · USNational Center for Toxicological Research · USUniversity of Kentucky · US

Funding

Force Validated Heart Valve Surgical Planning ToolR15HL145585 · NHLBI · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI JENSEN, MORTEN OLGAARD · 2019 to 2019
$417k
NHLBI NIH HHS R15 HL145585
6 · The paper itself

Abstract

backgroundHeart valve computational models require high quality geometric input data, commonly obtained using micro-computed tomography. Whether in the open or closed configuration, most studies utilize dry valves, which poses significant challenges including gravitational and surface tension effects along with desiccation induced mechanical changes.

objectiveThese challenges are overcome by scanning in a stress-free configuration in fluid. Utilizing fluid backgrounds however reduces overall contrast due to the similar density of fluid and tissue.

methodsThe work presented here demonstrates imaging of the mitral valve by utilizing an iodine-based staining solution to improve the contrast of valve tissue against a fluid background and investigates the role of stain time and concentration.

resultsIt is determined that an Olea europaea oil bath with a relatively high concentration, short stain time approach produces high quality imagery suitable for creating accurate 3D renderings.

conclusionsMicro-CT scanning of heart valves in fluid is shown to be feasible using iodine staining techniques.

Indexed as

Contrast-EnhancedMicroCTMitral ValveμCT

Identifiers

PMID34326554
PMCPMC8315378
OpenAlexW3097941500

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.