Evidence map›Paper›PMID 34326545›Full record

ArticleNature genetics2021

Variably methylated retrotransposons are refractory to a range of environmental perturbations.

Tessa M Bertozzi, Jessica L Becker, Georgina E T Blake, Amita Bansal, Duy K Nguyen, Denise S Fernandez-Twinn, Susan E Ozanne, Marisa S Bartolomei, Rebecca A Simmons, Erica D Watson and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Tessa M BertozziDepartment of Genetics, University of Cambridge, Cambridge, UK.
Jessica L BeckerDepartment of Genetics, University of Cambridge, Cambridge, UK.
Georgina E T BlakeDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Amita BansalCenter for Research on Reproduction and Women's Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8716-9922
Duy K NguyenDepartment of Cell and Developmental Biology, Perelman School of Medicine, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA.
Denise S Fernandez-TwinnUniversity of Cambridge Metabolic Research Laboratories and Medical Research Council Metabolic Diseases Unit, Wellcome Trust Medical Research Council Institute of Metabolic Science, Cambridge, UK.ORCID http://orcid.org/0000-0003-2610-277X
Susan E OzanneUniversity of Cambridge Metabolic Research Laboratories and Medical Research Council Metabolic Diseases Unit, Wellcome Trust Medical Research Council Institute of Metabolic Science, Cambridge, UK.
Marisa S BartolomeiCenter of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rebecca A SimmonsCenter for Research on Reproduction and Women's Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Erica D WatsonDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-4496-2271
Anne C Ferguson-SmithDepartment of Genetics, University of Cambridge, Cambridge, UK. afsmith@gen.cam.ac.uk.ORCID http://orcid.org/0000-0002-7608-5894
University of Cambridge · GBUniversity of Pennsylvania · USWellcome/MRC Institute of Metabolic Science · GBAustralian National University · AUChildren's Hospital of Philadelphia · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Transgenerational effects of endocrine disruptors: epigenetics and physiologyR01ES023284 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S., SIMMONS, REBECCA A · 2013 to 2017
$2.1M
Biotechnology and Biological Sciences Research Council BB/G020930/1British Heart Foundation RG/17/12/33167British Heart Foundation (BHF) RG/17/12/33167Medical Research Council MC_UU_00014/4Medical Research Council MC_UU_12012/4Medical Research Council MR/R009791/1NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES023284Wellcome Trust 210757Wellcome Trust 210757/Z/18/ZWellcome Trust WT095606
6 · The paper itself

Abstract

The agouti viable yellow (A

Indexed as

DNA MethylationRetroelementsAnimalsBenzhydryl CompoundsBisphenol A CompoundsDietEndocrine DisruptorsEpigenesis, GeneticFemaleFerredoxin-NADP ReductaseFolic AcidFolic Acid DeficiencyGene Expression RegulationMaleMiceMice, Inbred C57BLBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEndocrine DisruptorsFerredoxin-NADP ReductaseFolic Acidmethionine synthase reductasePhenolsRetroelements

Identifiers

PMID34326545
PMCPMC7611517
OpenAlexW3183415132

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.