ReviewNature reviews. Neuroscience2021
Towards real-world generalizability of a circuit for action-stopping.
Review in Nature reviews. Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The influence of emotional stimuli on response inhibition: a systematic review in non-clinical adults.Frontiers in psychology · 2025Pooled it
- Has stopping stopped making sense? Disentangling the processes elicited by complex action cancellation paradigms.Cognitive, affective & behavioral neuroscience · 2026Review
- Effects of single-session transcranial direct current stimulation on response inhibition in stop-signal task performance: A meta-analysis and systematic review.General psychiatry · 2026Article
- Temporal Dynamics of EEG Reflect Continuous Error Correction during Force Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A cortico-subthalamic circuit rapidly engages and releases inhibition of specific movements depending on the environmental context.PLoS biology · 2026Article
- Integrative genomics reveal genetic links of chronic cough with risk factors and brain regional volumes.ERJ open research · 2026Article
- Cortico-basal ganglia dynamics of global and selective response inhibition in humans.bioRxiv : the preprint server for biology · 2026Article
- Unpacking response inhibition in animals - part 1: a conceptual framework.Animal cognition · 2026Article
- Instrumented gait characteristics and short-term changes after CAREN training in ischemic stroke: a pilot study.Frontiers in psychiatry · 2026Article
- Response Inhibition in borderline personality disorder assessed with a gamified stop signal task.Scientific reports · 2025Article
- White matter lesions associated with the reemergence of grasp reflexes in patients with idiopathic normal pressure hydrocephalus.Fluids and barriers of the CNS · 2025Article
- The songbird basal ganglia connectome.bioRxiv : the preprint server for biology · 2025Article
- Stopping Muscle Contractions and Relaxations during Action Inhibition Involves Global and Targeted Control Dependent on Muscle State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Large-scale neural network correlates of response inhibition associated with antidepressant response in major depressive disorder.BMC psychiatry · 2025Article
- Global Motor System Suppression as the Primary Mechanism of Human Action Stopping: Challenging the Pause-Then-Cancel Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Two modes in the absolute velocity statistics in cautious walks of laboratory rodents.Biophysical journal · 2025Article
- Corticospinal excitability during timed interception depends on the speed of the moving target.Journal of neurophysiology · 2025Article
- Parietal cortex is recruited by frontal and cingulate areas to support action monitoring and updating during stopping.NeuroImage · 2025Article
- Green-to-red spectral labeling: A novel polysynaptic retrograde tracing strategy in the marker footprint mouse model.Animal models and experimental medicine · 2025Article
- Brain mechanisms underlying the inhibitory control of thought.Nature reviews. Neuroscience · 2025Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Two decades of cross-species neuroscience research on rapid action-stopping in the laboratory has provided motivation for an underlying prefrontal-basal ganglia circuit. Here we provide an update of key studies from the past few years. We conclude that this basic neural circuit is on increasingly firm ground, and we move on to consider whether the action-stopping function implemented by this circuit applies beyond the simple laboratory stop signal task. We advance through a series of studies of increasing 'real-worldness', starting with laboratory tests of stopping of speech, gait and bodily functions, and then going beyond the laboratory to consider neural recordings and stimulation during moments of control presumably required in everyday activities such as walking and driving. We end by asking whether stopping research has clinical relevance, focusing on movement disorders such as stuttering, tics and freezing of gait. Overall, we conclude there are hints that the prefrontal-basal ganglia action-stopping circuit that is engaged by the basic stop signal task is recruited in myriad scenarios; however, truly proving this for real-world scenarios requires a new generation of studies that will need to overcome substantial technical and inferential challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.