Evidence map›Paper›PMID 34326461›Full record

ArticleCommunications biology2021

FIP200 restricts RNA virus infection by facilitating RIG-I activation.

Lingyan Wang, Kun Song, Wenzhuo Hao, Yakun Wu, Girish Patil, Fang Hua, Yiwen Sun, Chaoqun Huang, Jerry Ritchey, Clinton Jones and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Autophagy and SARS-CoV-2-Old Players in New Games.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Lingyan Wang *Department of Microbiology and Immunology, Tulane University, New Orleans, LA, USA.
Kun Song *Department of Microbiology and Immunology, Tulane University, New Orleans, LA, USA.
Wenzhuo Hao *Department of Microbiology and Immunology, Tulane University, New Orleans, LA, USA.
Yakun Wu *Department of Microbiology and Immunology, Tulane University, New Orleans, LA, USA.
Girish PatilDepartment of Physiological Sciences, Oklahoma State University, Stillwater, OK, USA.
Fang HuaDepartment of Microbiology and Immunology, Tulane University, New Orleans, LA, USA.
Yiwen SunDepartment of Microbiology and Immunology, Tulane University, New Orleans, LA, USA.
Chaoqun HuangDepartment of Physiological Sciences, Oklahoma State University, Stillwater, OK, USA.
Jerry RitcheyDepartment of Pathology, Oklahoma State University, Stillwater, OK, USA.
Clinton JonesDepartment of Pathology, Oklahoma State University, Stillwater, OK, USA.
Lin LiuDepartment of Physiological Sciences, Oklahoma State University, Stillwater, OK, USA.
Jun-Lin GuanDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Shitao LiDepartment of Microbiology and Immunology, Tulane University, New Orleans, LA, USA. sli38@tulane.edu.
Tulane University · USOklahoma State University · USUniversity of Cincinnati Medical Center · US

Funding

ZFC3H1 Regulation of Host Defense and Influenza A Virus PathogenesisP20GM103648 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI CHENG, YONG · 2013 to 2022
$22.3M
Role of FIP200 in RIG-I-mediated innate immunityR01AI141399 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI LI, SHITAO · 2019 to 2023
$1.7M
Taxilin Alpha Regulates DNA-Mediated and Interferon-Dependent Innate ImmunityR15AI126360 · NIAID · OKLAHOMA STATE UNIVERSITY STILLWATER · PI LI, SHITAO · 2017 to 2017
$432k
Regulation of cGAS-Mediated Cytosolic DNA Sensing PathwayR21AI137750 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI LI, SHITAO · 2018 to 2019
$413k
NIAID NIH HHS R01 AI141399NIAID NIH HHS R15 AI126360NIAID NIH HHS R21 AI137750NIGMS NIH HHS P20 GM103648
6 · The paper itself

Abstract

Retinoic acid-inducible gene I (RIG-I) senses viral RNA and instigates an innate immune signaling cascade to induce type I interferon expression. Currently, the regulatory mechanisms controlling RIG-I activation remain to be fully elucidated. Here we show that the FAK family kinase-interacting protein of 200 kDa (FIP200) facilitates RIG-I activation. FIP200 deficiency impaired RIG-I signaling and increased host susceptibility to RNA virus infection. In vivo studies further demonstrated FIP200 knockout mice were more susceptible to RNA virus infection due to the reduced innate immune response. Mechanistic studies revealed that FIP200 competed with the helicase domain of RIG-I for interaction with the two tandem caspase activation and recruitment domains (2CARD), thereby facilitating the release of 2CARD from the suppression status. Furthermore, FIP200 formed a dimer and facilitated 2CARD oligomerization, thereby promoting RIG-I activation. Taken together, our study defines FIP200 as an innate immune signaling molecule that positively regulates RIG-I activation.

Indexed as

A549 CellsAnimalsAutophagy-Related ProteinsChlorocebus aethiopsCommon ColdCoronavirus InfectionsCoronavirus OC43, HumanDEAD Box Protein 58HEK293 CellsHumansMiceMice, KnockoutRAW 264.7 CellsRhabdoviridae InfectionsVero CellsVesicular StomatitisAutophagy-Related ProteinsDdx58 protein, mouseDEAD Box Protein 58Rb1cc1 protein, mouse

Identifiers

PMID34326461
PMCPMC8322336
OpenAlexW3184546953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.