ArticleScientific reports2021
A bioimpedance-based monitor for real-time detection and identification of secondary brain injury.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Exploring and translating novel approaches targeting the choroid plexus for the treatment of hydrocephalus: a literature review.Fluids and barriers of the CNS · 2026Review
- Applications of bioimpedance measurement in clinical and allied fields: a comprehensive review.Biomedical engineering online · 2026Review
- A framework of digital biomarkers for neurodegenerative diseases.Nature reviews bioengineering · 2026Article
- A Non-Stationary Model for Analysis of Impedance Spectra of Biological Samples.Entropy (Basel, Switzerland) · 2026Article
- Exploring Bio-Impedance Sensing for Intelligent Wearable Devices.Bioengineering (Basel, Switzerland) · 2025Article
- Developing a Vital Signal Detection Electrode for Fabric Substrate Using a High-Performance Conductive Carbon-Based Ink.IEEE open journal of engineering in medicine and biology · 2025Article
- Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury.Molecules (Basel, Switzerland) · 2023Article
- Electrical bioimpedance measurement and near-infrared spectroscopy in pediatric postoperative neurocritical care: a prospective observational study.Frontiers in neurology · 2023Article
- Novel Electrode Placement in Electrical Bioimpedance-Based Stroke Detection: Effects on Current Penetration and Injury Characterization in a Finite Element Model.IEEE transactions on bio-medical engineering · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Secondary brain injury impacts patient prognosis and can lead to long-term morbidity and mortality in cases of trauma. Continuous monitoring of secondary injury in acute clinical settings is primarily limited to intracranial pressure (ICP); however, ICP is unable to identify essential underlying etiologies of injury needed to guide treatment (e.g. immediate surgical intervention vs medical management). Here we show that a novel intracranial bioimpedance monitor (BIM) can detect onset of secondary injury, differentiate focal (e.g. hemorrhage) from global (e.g. edema) events, identify underlying etiology and provide localization of an intracranial mass effect. We found in an in vivo porcine model that the BIM detected changes in intracranial volume down to 0.38 mL, differentiated high impedance (e.g. ischemic) from low impedance (e.g. hemorrhagic) injuries (p < 0.001), separated focal from global events (p < 0.001) and provided coarse 'imaging' through localization of the mass effect. This work presents for the first time the full design, development, characterization and successful implementation of an intracranial bioimpedance monitor. This BIM technology could be further translated to clinical pathologies including but not limited to traumatic brain injury, intracerebral hemorrhage, stroke, hydrocephalus and post-surgical monitoring.
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Registered trials
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