ArticleScientific reports2021
Maternal biological age assessed in early pregnancy is associated with gestational age at birth.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- The Mediating Role of Social and Environmental Determinants of Health in the Association Between Race and Preterm Birth Risk.Journal of women's health (2002) · 2025Article
- Clock Proteins Have the Potential to Improve Term Delivery Date Prediction: A Proof-of-Concept Study.Life (Basel, Switzerland) · 2025Article
- Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study.BMC medicine · 2024Article
- Epigenetic Responses to Nonchemical Stressors: Potential Molecular Links to Perinatal Health Outcomes.Current environmental health reports · 2024Review
- Accelerated epigenetic clock aging in maternal peripheral blood and preterm birth.American journal of obstetrics and gynecology · 2024Article
- The Social Context of Pregnancy, Respectful Maternity Care, Biomarkers of Weathering, and Postpartum Mental Health Inequities: A Scoping Review.International journal of environmental research and public health · 2024Article
- An explanatory model of quality of life in high-risk pregnant women in Korea: a structural equation model.Korean journal of women health nursing · 2023Article
- Association between kidney function and biological age: a China Health and Retirement Longitudinal Study.Frontiers in public health · 2023Article
- Genetics, epigenetics, and transcriptomics of preterm birth.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022Review
- Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines.Clinical epigenetics · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Maternal age is an established predictor of preterm birth independent of other recognized risk factors. The use of chronological age makes the assumption that individuals age at a similar rate. Therefore, it does not capture interindividual differences that may exist due to genetic background and environmental exposures. As a result, there is a need to identify biomarkers that more closely index the rate of cellular aging. One potential candidate is biological age (BA) estimated by the DNA methylome. This study investigated whether maternal BA, estimated in either early and/or late pregnancy, predicts gestational age at birth. BA was estimated from a genome-wide DNA methylation platform using the Horvath algorithm. Linear regression methods assessed the relationship between BA and pregnancy outcomes, including gestational age at birth and prenatal perceived stress, in a primary and replication cohort. Prenatal BA estimates from early pregnancy explained variance in gestational age at birth above and beyond the influence of other recognized preterm birth risk factors. Sensitivity analyses indicated that this signal was driven primarily by self-identified African American participants. This predictive relationship was sensitive to small variations in the BA estimation algorithm. Benefits and limitations of using BA in translational research and clinical applications for preterm birth are considered.
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Registered trials
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