ArticleNature communications2021
Simultaneous construction of axial and planar chirality by gold/TY-Phos-catalyzed asymmetric hydroarylation.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Construction of remote dual stereocenters by electrochemical cobalt-catalyzed enantioselective desymmetrization.Nature communications · 2026Article
- Copper-catalyzed atroposelective hydroarylation of 1-alkynylindoles.Nature communications · 2025Article
- Organocatalytic Kinetic Resolution of Ferroceno[JACS Au · 2025Article
- Practical Synthesis of Chiral Ferrocenenylphosphino-Gold(I) Catalysts and NEST Analysis of the Enantioinduction.ACS catalysis · 2025Article
- Enantiopure Turbo Chirality Targets in Tri-Propeller Blades: Design, Asymmetric Synthesis, and Computational Analysis.Molecules (Basel, Switzerland) · 2025Article
- Atroposelective synthesis of biaxial bridged eight-membered terphenyls via a Co/SPDO-catalyzed aerobic oxidative coupling/desymmetrization of phenols.Nature communications · 2024Article
- Enantioselective Rh(I)-Catalyzed C-H Arylation of Ferroceneformaldehydes.ACS central science · 2023Article
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Authors and funding
6 authors.
Funding
Abstract
The simultaneous construction of two different chiralities via a simple operation poses considerable challenge. Herein a cationic gold-catalyzed asymmetric hydroarylation of ortho-alkynylaryl ferrocenes derivatives is developed, which enable the simultaneous construction of axial and planar chirality. The here identified TY-Phos derived gold complex is responsible for the high yield, good diastereoselectivity (>20:1 dr), high enantioselectivities (up to 99% ee) and mild conditions. The catalyst system also shows potential application in the synthesis of chiral biaryl compounds. The cause of high enantioselectivity of this hydroarylation is investigated with density functional theory caculation.
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Registered trials
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