Evidence map›Paper›PMID 34326306›Full record

ArticleLight, science & applications2021

Neural network-based image reconstruction in swept-source optical coherence tomography using undersampled spectral data.

Yijie Zhang, Tairan Liu, Manmohan Singh, Ege Çetintaş, Yilin Luo, Yair Rivenson, Kirill V Larin, Aydogan Ozcan

Abstract read
In one paragraph

Article in Light, science & applications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Light People: Professor Aydogan Ozcan.Light, science & applications · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yijie Zhang *Electrical and Computer Engineering Department, University of California, Los Angeles, CA, 90095, USA.
Tairan Liu *Electrical and Computer Engineering Department, University of California, Los Angeles, CA, 90095, USA.
Manmohan SinghDepartment of Biomedical Engineering, University of Houston, Houston, TX, 77204, USA.
Ege ÇetintaşElectrical and Computer Engineering Department, University of California, Los Angeles, CA, 90095, USA.
Yilin LuoElectrical and Computer Engineering Department, University of California, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0002-4611-3049
Yair RivensonElectrical and Computer Engineering Department, University of California, Los Angeles, CA, 90095, USA.
Kirill V LarinDepartment of Biomedical Engineering, University of Houston, Houston, TX, 77204, USA.
Aydogan OzcanElectrical and Computer Engineering Department, University of California, Los Angeles, CA, 90095, USA. ozcan@ucla.edu.ORCID http://orcid.org/0000-0002-0717-683X

Funding

Structural and Molecular Phenotyping of Embryonic Development through Multi-Modal Optical ImagingR01HL146745 · NHLBI · UNIVERSITY OF HOUSTON · PI MAYERICH, DAVID · 2019 to 2023
$3.7M
Biomechanics of early mammalian cardiogenesisR01HD096335 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LARINA, IRINA · 2018 to 2022
$2.8M
Prenatal alcohol/cannabinoid co-exposures and fetal brain developmentR01AA028406 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI LARIN, KIRILL V, MIRANDA, RAJESH C · 2020 to 2024
$2.6M
In vivo analysis of mammalian fertilizationR01EB027099 · NIBIB · BAYLOR COLLEGE OF MEDICINE · PI LARINA, IRINA · 2019 to 2022
$2.5M
NHLBI NIH HHS R01 HL146745NIAAA NIH HHS R01 AA028406NIBIB NIH HHS R01 EB027099NICHD NIH HHS R01 HD096335
6 · The paper itself

Abstract

Optical coherence tomography (OCT) is a widely used non-invasive biomedical imaging modality that can rapidly provide volumetric images of samples. Here, we present a deep learning-based image reconstruction framework that can generate swept-source OCT (SS-OCT) images using undersampled spectral data, without any spatial aliasing artifacts. This neural network-based image reconstruction does not require any hardware changes to the optical setup and can be easily integrated with existing swept-source or spectral-domain OCT systems to reduce the amount of raw spectral data to be acquired. To show the efficacy of this framework, we trained and blindly tested a deep neural network using mouse embryo samples imaged by an SS-OCT system. Using 2-fold undersampled spectral data (i.e., 640 spectral points per A-line), the trained neural network can blindly reconstruct 512 A-lines in 0.59 ms using multiple graphics-processing units (GPUs), removing spatial aliasing artifacts due to spectral undersampling, also presenting a very good match to the images of the same samples, reconstructed using the full spectral OCT data (i.e., 1280 spectral points per A-line). We also successfully demonstrate that this framework can be further extended to process 3× undersampled spectral data per A-line, with some performance degradation in the reconstructed image quality compared to 2× spectral undersampling. Furthermore, an A-line-optimized undersampling method is presented by jointly optimizing the spectral sampling locations and the corresponding image reconstruction network, which improved the overall imaging performance using less spectral data points per A-line compared to 2× or 3× spectral undersampling results. This deep learning-enabled image reconstruction approach can be broadly used in various forms of spectral-domain OCT systems, helping to increase their imaging speed without sacrificing image resolution and signal-to-noise ratio.

Identifiers

PMID34326306
PMCPMC8322159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.