ArticleScience (New York, N.Y.)2021
Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion.
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Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
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47 citing papers in PubMed, 79 citations in OpenAlex.
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- A decrease in Flavonifractor plautii and its product, phytosphingosine, predisposes individuals with phlegm-dampness constitution to metabolic disorders.Cell discovery · 2025Article
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- TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury.Frontiers in immunology · 2025Article
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Authors and funding
23 authors at 6 institutions in 1 country.
Ruth ChoaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-4798-7565
Junichiro TohyamaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-9779-5713
Shogo WadaCardiovascular Institute and the Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Hu MengInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-2224-5431
Jian HuDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-2852-7675
Mariko OkumuraDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Rebecca M MayArkana Laboratories, Little Rock, AR, USA.
Tanner F RobertsonDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-4336-3760
Ruth-Anne Langan PaiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9413-7611
Arben NaceDepartment of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Christian HopkinsDepartment of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1444-0691
Elizabeth A JacobsenDivision of Allergy, Asthma and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, AZ, USA.ORCID 0000-0003-2956-753X
Malay HaldarDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Garret A FitzGeraldInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-5885-6819
Edward M BehrensDivision of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-4603-7963
Andy J MinnDepartment of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Patrick SealeInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
George CotsarelisDepartment of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Brian KimDivision of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-8100-7161
John T SeykoraDepartment of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-0383-031X
Mingyao LiDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-2422-9494
Zoltan AranyCardiovascular Institute and the Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1368-2453
Taku KambayashiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. taku.kambayashi@pennmedicine.upenn.edu.ORCID 0000-0002-6753-3181
University of Pennsylvania · USChildren's Hospital of Philadelphia · USTranslational Therapeutics (United States) · USArkana Laboratories · USWashington University in St. Louis · USWinnMed · US
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Patrick Seale · 1986 to 2026
$48.3MHEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1MStudy Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6MNeuroimmune Regulation of Atopic DermatitisR01AR070116 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2016 to 2021
$3.8MThe role of the T cell receptor in regulatory T cell homeostasis and expansionR01HL111501 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAMBAYASHI, TAKU · 2012 to 2020
$3.6MMetabolic Phenotyping in Live Models of Obesity and DiabetesU2CDK135066 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias · 2023 to 2026
$3.5MUnderstanding molecular mechanisms underlying the formation of the blue nevus andP30AR057217 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI STANLEY, JOHN R · 2009 to 2013
$3.2MIL-33 Blockade as a Novel Therapeutic for T-cell Mediated Hypercytokinemia SyndromesR01AI121250 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI BEHRENS, EDWARD M, KAMBAYASHI, TAKU · 2016 to 2020
$3.0MDiacylglycerol kinase in airway smooth muscle functionsR01HL146645 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI DESHPANDE, DEEPAK A, KAMBAYASHI, TAKU · 2019 to 2024
$2.8MIndirect calorimetry cages equipped for glucose and blood pressure telemetryS10OD025098 · OD · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2019 to 2019
$750kNHLBI NIH HHS R01 HL111501NHLBI NIH HHS R01 HL146645NHLBI NIH HHS T32 HL007439NIAID NIH HHS R01 AI121250NIAMS NIH HHS P30 AR057217NIAMS NIH HHS P30 AR069589NIAMS NIH HHS R01 AR070116NIDDK NIH HHS P30 DK019525NIDDK NIH HHS U2C DK135066NIH HHS S10 OD025098
Abstract
Emerging studies indicate that the immune system can regulate systemic metabolism. Here, we show that thymic stromal lymphopoietin (TSLP) stimulates T cells to induce selective white adipose loss, which protects against obesity, improves glucose metabolism, and mitigates nonalcoholic steatohepatitis. Unexpectedly, adipose loss was not caused by alterations in food intake, absorption, or energy expenditure. Rather, it was induced by the excessive loss of lipids through the skin as sebum. TSLP and T cells regulated sebum release and sebum-associated antimicrobial peptide expression in the steady state. In human skin,
Indexed as
Adaptive ImmunityAdipose Tissue, WhiteAnimalsCytokinesDietGlucoseHomeostasisHumansImmunoglobulinsLipid MetabolismMiceNon-alcoholic Fatty Liver DiseaseObesityPore Forming Cytotoxic ProteinsReceptors, CytokineSebaceous GlandsCytokinesGlucoseImmunoglobulinsPore Forming Cytotoxic ProteinsReceptors, CytokineThymic Stromal LymphopoietinTslpr protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.