Evidence map›Paper›PMID 34326207›Full record

ArticleScience (New York, N.Y.)2021

Temporal shifts in antibiotic resistance elements govern phage-pathogen conflicts.

Kristen N LeGault, Stephanie G Hays, Angus Angermeyer, Amelia C McKitterick, Fatema-Tuz Johura, Marzia Sultana, Tahmeed Ahmed, Munirul Alam, Kimberley D Seed

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Prophage: agent provocateur?Archives of microbiology · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Genomic islands inNAR genomics and bioinformatics · 2025
    Article
  13. Metagenomic analysis of bacteriome and phageome of wastewater from a ceramic factory in Türkiye.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Defence systems encoded by core genomic islands of seventh pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  18. Phage defence-system abundances vary across environments and increase with viral density.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  19. Lineage-specific defence systems of pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristen N LeGaultDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.ORCID 0000-0002-9896-6983
Stephanie G HaysDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.ORCID 0000-0001-8829-2586
Angus AngermeyerDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.ORCID 0000-0002-9072-4760
Amelia C McKitterickDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.ORCID 0000-0001-7290-2781
Fatema-Tuz Johuraicddr,b, formerly International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Marzia Sultanaicddr,b, formerly International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Tahmeed Ahmedicddr,b, formerly International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.ORCID 0000-0002-4607-7439
Munirul Alamicddr,b, formerly International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Kimberley D SeedDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA. kseed@berkeley.edu.ORCID 0000-0002-0139-1600

Funding

Phage resistance and mobile genetic elements in Vibrio choleraeR01AI127652 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SEED, KIMBERLEY DIANE · 2016 to 2025
$4.6M
Molecular mechanisms driving the coevolution of clinical isolates of phages and epidemic Vibrio choleraeR01AI153303 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Kimberley Diane Seed · 2020 to 2026
$4.3M
NIAID NIH HHS R01 AI127652NIAID NIH HHS R01 AI153303
6 · The paper itself

Abstract

Bacteriophage predation selects for diverse antiphage systems that frequently cluster on mobilizable defense islands in bacterial genomes. However, molecular insight into the reciprocal dynamics of phage-bacterial adaptations in nature is lacking, particularly in clinical contexts where there is need to inform phage therapy efforts and to understand how phages drive pathogen evolution. Using time-shift experiments, we uncovered fluctuations in

Indexed as

Interspersed Repetitive SequencesBacteriolysisCholeraConjugation, GeneticDrug Resistance, BacterialEpigenesis, GeneticFecesGammaproteobacteriaGenes, BacterialGenes, ViralGenome, BacterialGenome, ViralHost SpecificityHumansMicrobial InteractionsMyoviridaeViral Proteins

Identifiers

PMID34326207
PMCPMC9064180

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.