Evidence map›Paper›PMID 34326180›Full record

ArticleNeurology2021

COVID-19 and Vaccination in the Setting of Neurologic Disease: An Emerging Issue in Neurology.

Elisabeth B Marsh, Michael Kornberg, Kevin Kessler, Ihtsham Haq, Anup D Patel, Avindra Nath, Becky Schierman, Lyell K Jones, Quality Committee of the American Academy of Neurology*

Abstract read
In one paragraph

Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Is there still hesitancy towards SARS-CoV-2 vaccination among people with neurological disease- a survey of the NeuroCOVID-19 task force of the European Academy of Neurology.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  8. Reversible neurological and brain MRI changes following COVID-19 vaccination: A case report.Journal of neuroradiology = Journal de neuroradiologie · 2022
    Article
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  15. The relationship between myasthenia gravis and COVID-19: a systematic review.The Egyptian journal of neurology, psychiatry and neurosurgery · 2022
    Review
  16. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elisabeth B MarshThe Johns Hopkins School of Medicine, Baltimore, MD ebmarsh@jhmi.edu.ORCID 0000-0002-2385-5074
Michael KornbergThe Johns Hopkins School of Medicine, Baltimore, MD.ORCID 0000-0003-2588-7325
Kevin KesslerThe University of Virginia Medical Center, Charlottesville, VA.
Ihtsham HaqThe University of Miami Miller School of Medicine, Miami, FL.ORCID 0000-0002-8001-8440
Anup D PatelNationwide Children's Hospital, Columbus, OH.ORCID 0000-0001-9313-1541
Avindra NathThe National Institutes of Health, Bethesda, MD.ORCID 0000-0003-0927-5855
Becky SchiermanThe American Academy of Neurology, Minneapolis, MN.
Lyell K JonesThe Mayo Clinic, Rochester, MN.ORCID 0000-0002-5851-8705
Quality Committee of the American Academy of Neurology*

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic caused by the SARS-CoV-2 virus has left many unanswered questions for patients with neurological disorders and the providers caring for them. Elderly and immunocompromised patients are at increased risk for severe symptoms due to COVID-19, and the virus may increase symptoms of underlying neurological illness, particularly for those with significant bulbar and respiratory weakness or other neurologic disability. Emerging SARS-CoV-2 vaccines offer substantial protection from symptomatic infection, but both patients and providers may have concerns regarding theoretical risks of vaccination, including vaccine safety and efficacy in the context of immunotherapy and the potential for precipitating or exacerbating neurological symptoms. In this statement on behalf of the Quality Committee of the AAN we review the current literature, focusing on COVID-19 infection in adults with neurological disease, in order to elucidate risks and benefits of vaccination in these individuals. Based on existing evidence, neurologists should recommend COVID-19 vaccination to their patients. For those patients being treated with immunotherapies, attention should be paid to timing of vaccination with respect to treatment and the potential for an attenuated immune response.

Indexed as

COVID-19 vaccineimmunosuppressioninfectionneurological disease

Identifiers

PMID34326180
PMCPMC8575134

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.