Evidence map›Paper›PMID 34326141›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Acetaldehyde Excitation of Lateral Habenular Neurons via Multiple Cellular Mechanisms.

Weiyuan Huang, Wanhong Zuo, Lixin Chen, Liwei Wang, George Tewfik, Rao Fu, Jiayi Zheng, Ding Li, Jiang-Hong Ye

Abstract read
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In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weiyuan HuangDepartment of Anesthesiology, Pharmacology and Physiology, & Neuroscience Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, 07103.
Wanhong ZuoDepartment of Anesthesiology, Pharmacology and Physiology, & Neuroscience Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, 07103.
Lixin ChenDepartment of Physiology, and Pharmacology, Medical College, Jinan University, Guangzhou, 510632 China.
Liwei WangDepartment of Physiology, and Pharmacology, Medical College, Jinan University, Guangzhou, 510632 China.
George TewfikDepartment of Anesthesiology, Pharmacology and Physiology, & Neuroscience Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, 07103.
Rao FuDepartment of Anesthesiology, Pharmacology and Physiology, & Neuroscience Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, 07103.
Jiayi ZhengDepartment of Anesthesiology, Pharmacology and Physiology, & Neuroscience Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, 07103.
Ding LiDepartment of Anesthesiology, Pharmacology and Physiology, & Neuroscience Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, 07103.
Jiang-Hong YeDepartment of Anesthesiology, Pharmacology and Physiology, & Neuroscience Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, 07103 ye@njms.rutgers.edu.ORCID 0000-0003-2545-4239

Funding

Mechanisms of regulation of ethanol intake by lateral habenulaR01AA021657 · NIAAA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI YE, JIANG-HONG · 2013 to 2017
$1.8M
Role of Rostromedial Tegmental Nucleus in alcohol addictionR01AA022292 · NIAAA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI YE, JIANG-HONG · 2014 to 2018
$1.7M
NIAAA NIH HHS R01 AA021657NIAAA NIH HHS R01 AA022292
6 · The paper itself

Abstract

Acetaldehyde (ACD), the first metabolite of ethanol, is implicated in several of ethanol's actions, including the reinforcing and aversive effects. The neuronal mechanisms underlying ACD's aversive effect, however, are poorly understood. The lateral habenula (LHb), a regulator of midbrain monoaminergic centers, is activated by negative valence events. Although the LHb has been linked to the aversive responses of several abused drugs, including ethanol, little is known about ACD. We, therefore, assessed ACD's action on LHb neurons in rats. The results showed that intraperitoneal injection of ACD increased cFos protein expression within the LHb and that intra-LHb infusion of ACD induced conditioned place aversion in male rats. Furthermore, electrophysiological recording in brain slices of male and female rats showed that bath application of ACD facilitated spontaneous firing and glutamatergic transmission. This effect of ACD was potentiated by an aldehyde dehydrogenase (ALDH) inhibitor, disulfiram (DS), but attenuated by the antagonists of dopamine (DA) receptor (DAR) subtype 1 (SCH23390) and subtype 2 (raclopride), and partly abolished by the pretreatment of DA or DA reuptake blocker (GBR12935; GBR). Moreover, application of ACD initiated a depolarizing inward current (

Indexed as

AcetaldehydeAnimalsAvoidance LearningDisulfiramDopamine AntagonistsDopamine Uptake InhibitorsGlutamic AcidHabenulaMaleNeuronsProto-Oncogene Proteins c-fosRatsRats, Sprague-DawleyReceptors, DopamineSynaptic TransmissionAcetaldehydeDisulfiramDopamine AntagonistsDopamine Uptake InhibitorsGlutamic AcidProto-Oncogene Proteins c-fosReceptors, DopamineaversioncAMP-PKAdopamine receptorelectrophysiologyHCN channelsimmunochemistry

Identifiers

PMID34326141
PMCPMC8425984

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.