Evidence map›Paper›PMID 34326138›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2021

Tetrahydrocannabinol and Its Major Metabolites Are Not (or Are Poor) Substrates or Inhibitors of Human P-Glycoprotein [ATP-Binding Cassette (ABC) B1] and Breast Cancer Resistance Protein (ABCG2).

Xin Chen, Jashvant D Unadkat, Qingcheng Mao

Open access · bronzeAbstract read
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
  5. Article
  6. Article
  7. Article
  8. Are ΔInternational journal of molecular sciences · 2024
    Article
  9. Review
  10. Article
  11. Cannabis Pharmacogenomics: A Path to Personalized Medicine.Current issues in molecular biology · 2023
    Review
  12. Maternal and Fetal Exposure to (-)-ΔDrug metabolism and disposition: the biological fate of chemicals · 2023
    Article
  13. Characterizing and Quantifying Extrahepatic Metabolism of (-)-ΔDrug metabolism and disposition: the biological fate of chemicals · 2022
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xin ChenDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington.
Jashvant D UnadkatDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington.
Qingcheng MaoDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington qmao@uw.edu jash@uw.edu.
University of Washington · US

Funding

Understanding Fetal Exposure to Cannabinoids Through In Vitro and In Vivo StudiesP01DA032507 · NIDA · UNIVERSITY OF WASHINGTON · PI UNADKAT, JASHVANT D · 2013 to 2023
$12.4M
NIDA NIH HHS P01 DA032507
6 · The paper itself

Abstract

(-)-Δ

Indexed as

ATP Binding Cassette Transporter, Subfamily G, Member 2Neoplasm ProteinsAnimalsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily B, Member 1Biological Transport, ActiveCannabisDiketopiperazinesDogsDronabinolDrug InteractionsFluorescent DyesHeterocyclic Compounds, 4 or More RingsHumansIsoquinolinesMadin Darby Canine Kidney Cells11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl esterABCG2 protein, humanATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2DiketopiperazinesDronabinolFluorescent DyesHeterocyclic Compounds, 4 or More RingsIsoquinolineslucifer yellowNeoplasm ProteinsPsychotropic Drugs

Identifiers

PMID34326138
PMCPMC8626638
OpenAlexW3185863566

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.