Evidence map›Paper›PMID 34326111›Full record

ArticleBMJ case reports2021

Maple syrup urine disease associated with nephrotic syndrome in a Filipino child.

Ebner Bon G Maceda, Michelle E Abadingo, Cheryll J Magbanua-Calalo, Melissa A Dator, Lourdes Paula R Resontoc, Leniza De Castro-Hamoy, Mary Ann R Abacan, Mary Anne D Chiong, Sylvia C Estrada

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ebner Bon G MacedaDivision of Clinical Genetics, Department of Pediatrics, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines egmaceda@up.edu.ph.ORCID http://orcid.org/0000-0001-5414-7030
Michelle E AbadingoDivision of Clinical Genetics, Department of Pediatrics, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Cheryll J Magbanua-CalaloDivision of Clinical Genetics, Department of Pediatrics, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Melissa A DatorDivision of Pediatric Nephrology, Department of Pediatrics, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Lourdes Paula R ResontocDivision of Pediatric Nephrology, Department of Pediatrics, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Leniza De Castro-HamoyDivision of Clinical Genetics, Department of Pediatrics, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Mary Ann R AbacanDivision of Clinical Genetics, Department of Pediatrics, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Mary Anne D ChiongDivision of Clinical Genetics, Department of Pediatrics, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Sylvia C EstradaDivision of Clinical Genetics, Department of Pediatrics, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Philippine General Hospital · PH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 22-month-old female child with maple syrup urine disease (MSUD) presented with generalised oedema. Diagnostic evaluation revealed nephrotic range proteinuria, hypoalbuminaemia and dyslipidaemia supporting the diagnosis of nephrotic syndrome (NS). Diet, being at the core of the management plan for both MSUD and NS, necessitated regular monitoring and evaluation via dried blood spot collection of leucine. The opposing requirement for total protein for both disorders (that is protein restriction in MSUD and protein supplementation in NS) prompted a careful balancing act of the dietary management. The monitoring, which revealed normal leucine levels on multiple determinations, allowed an eventual increase in dietary protein and daily administration of albumin to address the NS. Dietary protein increase, both in total protein (3.5 g/kg/day) and natural protein (1 g/kg/day) levels, was instituted. It was observed that NS does not trigger leucinosis and allowed easing of protein restriction in MSUD.

Indexed as

Maple Syrup Urine DiseaseNephrotic SyndromeChildDietDietary ProteinsFemaleHumansInfantLeucineDietary ProteinsLeucinegeneticsmedical managementpaediatrics

Identifiers

PMID34326111
PMCPMC8323351
OpenAlexW3185354121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.