ArticleAJNR. American journal of neuroradiology2021
Dual-Layer Spectral CT Imaging of Upper Aerodigestive Tract Cancer: Analysis of Spectral Imaging Parameters and Impact on Tumor Staging.
Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Spectral CT-based radiomics signature for distinguishing malignant pulmonary nodules from benign.BMC cancer · 2023Trial
- Practical applications of photon-counting CT in oncology: an organ-based pictorial review.Insights into imaging · 2026Article
- Spectral CT and Photon-counting Detector CT: Principles and Applications in Neuroradiology.Radiology. Imaging cancer · 2026Review
- Dual-layer spectral CT for predicting spread through air spaces in lung adenocarcinoma: a dual-center study.European radiology · 2026Article
- The value of dual-layer detector spectral CT multiparameter imaging in distinguishing between benign lesions and carcinomas of the larynx and hypopharynx.Quantitative imaging in medicine and surgery · 2026Article
- Photon counting computed tomography in head and neck squamous cell carcinoma: iodine concentration and histopathological features.Journal of cancer research and clinical oncology · 2026Article
- Value of dual-layer spectral detector computed tomography in the diagnosis of benign/malignant solid solitary pulmonary nodules and establishment of a prediction model.Frontiers in oncology · 2023Article
- The diagnostic value of quantitative parameters on dual-layer detector-based spectral CT in identifying ischaemic stroke.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeDual-layer spectral CT is a novel technology that utilized conventional single-tube CT acquisition with a dual-layer detector for the separation of high and low-energy photons to create spectral data for material decomposition. We evaluated the spectral parameters of iodine density and Z-effective values in primary head and neck squamous cell carcinoma and determined its impact on local tumor staging. MATERIALS AND
methodsTwenty-one patients with primary head and neck squamous cell carcinoma and 15 healthy controls were retrospectively evaluated. Iodine density (milligram/milliliter) and Z-effective values were compared quantitatively between head and neck squamous cell carcinoma and normal neck mucosa. The receiver operating characteristic area under the curve determined the diagnostic performance of the spectral data for local staging. We compared conventional CT images without and with iodine density and Z-effective images to determine its impact on local tumor staging.
resultsPrimary head and neck squamous cell carcinoma showed higher mean iodine density (2.01 [SD, 0.26] mg/mL,
conclusionsDual-layer spectral iodine density and Z-effective values provided increased quantitative and qualitative differentiation between upper aerodigestive head and neck squamous cell carcinoma and normal mucosa. Increased tissue differentiation improved the local tumor staging accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.