Evidence map›Paper›PMID 34326065›Full record

ArticleeNeuro

Cre Recombinase Driver Mice Reveal Lineage-Dependent and -Independent Expression of Brs3 in the Mouse Brain.

Allison S Mogul, Colleen K Hadley, Haley S Province, Jordan Pauli, Oksana Gavrilova, Cuiying Xiao, Richard D Palmiter, Ramón A Piñol, Marc L Reitman

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Allison S MogulDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Colleen K HadleyDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Haley S ProvinceDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Jordan PauliDepartment of Biochemistry, Genome Sciences, and Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195.
Oksana GavrilovaMouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Cuiying XiaoDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Richard D PalmiterDepartment of Biochemistry, Genome Sciences, and Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195.ORCID 0000-0001-6587-0582
Ramón A PiñolDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Marc L ReitmanDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 marc.reitman@nih.gov.ORCID 0000-0002-0426-9475
National Institutes of Health · USHoward Hughes Medical Institute · US

Funding

Metabolic Studies of Mouse Models of Obesity and DiabetesZICDK070002 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GAVRILOVA, OKSANA · 2009 to 2025
$15.0M
Physiology and Pharmacology of BRS3 (Bombesin Receptor Subtype-3)ZIADK075057 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REITMAN, MARC L · 2011 to 2025
$7.1M
What can body temperature tell us about energy homeostasis?ZIADK075063 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REITMAN, MARC L · 2012 to 2025
$5.6M
Pharmacologic approaches to the treatment of obesityZIADK075062 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REITMAN, MARC L · 2012 to 2025
$5.5M
Howard Hughes Medical InstituteIntramural NIH HHS ZIA DK075057Intramural NIH HHS ZIA DK075062Intramural NIH HHS ZIA DK075063
6 · The paper itself

Abstract

Bombesin receptor subtype-3 (BRS3) is an orphan receptor that regulates energy homeostasis. We compared

Indexed as

IntegrasesReceptors, BombesinAnimalsBrainHypothalamusMiceMice, Transgenicbombesin receptor subtype 3Cre recombinaseIntegrasesReceptors, Bombesinbombesin receptor subtype-3BRS3Cre recombinase driver micedentate gyrushypothalamuslineage tracingparabrachial nucleus

Identifiers

PMID34326065
PMCPMC8371926
OpenAlexW3186444529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.