Evidence map›Paper›PMID 34325985›Full record

ArticleJournal of diabetes and its complications2021

Leptin receptor signaling is required for intact hypoglycemic counterregulation: A study in male Zucker rats.

Christopher D Morrison, Marina A DuVall, Cristal M Hill, Redin A Spann, David H McDougal

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes and its complications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christopher D MorrisonNeurosignaling Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Marina A DuVallNeurobiology of Metabolic Dysfunction Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Cristal M HillNeurosignaling Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Redin A SpannNeurosignaling Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
David H McDougalNeurobiology of Metabolic Dysfunction Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. Electronic address: David.McDougal@pbrc.edu.
Pennington Biomedical Research Center · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI JUDD E SHELLITO · 2012 to 2026
$69.1M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Astrocytes, Glucose Detection, and Counter-RegulationR01DK108765 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROGERS, RICHARD C. · 2016 to 2020
$2.1M
Glial-Neural Interactions in Autonomic ControlR01NS060664 · NINDS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROGERS, RICHARD C. · 2008 to 2012
$1.6M
NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK108765NIDDK NIH HHS U24 DK059637NIGMS NIH HHS U54 GM104940NINDS NIH HHS R01 NS060664
6 · The paper itself

Abstract

Hypoglycemia is a major barrier to clinical management of persons with diabetes. Emerging evidence supports a role for leptin in gating hypoglycemic counterregulation. This work demonstrates that male leptin receptor null, Zucker (fa/fa), rats display severe impairments in hypoglycemic counterregulation. Thus, augmenting leptin levels may have clinical utility for preventing hypoglycemia.

Indexed as

HypoglycemiaReceptors, LeptinAnimalsGlucagon-Like Peptide-1 ReceptorHypoglycemic AgentsLeptinMaleObesityRatsRats, ZuckerGlp1r protein, ratGlucagon-Like Peptide-1 ReceptorHypoglycemic AgentsLeptinReceptors, LeptinDiabetesHypoglycemiaLeptinLeptin receptorsZucker rats

Identifiers

PMID34325985
PMCPMC8435018
OpenAlexW3185307829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.