Evidence map›Paper›PMID 34325796›Full record

ArticleMethods in enzymology2021

Initiating protein synthesis with noncanonical monomers in vitro and in vivo.

Jeffery M Tharp, Joshua A Walker, Dieter Söll, Alanna Schepartz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in enzymology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Tuning tRNAs for improved translation.Frontiers in genetics · 2024
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jeffery M TharpDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, United States.
Joshua A WalkerDepartment of Chemistry, University of California, Berkeley, CA, United States.
Dieter SöllDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, United States; Department of Chemistry, Yale University, New Haven, CT, United States. Electronic address: dieter.soll@yale.edu.
Alanna SchepartzDepartment of Chemistry, University of California, Berkeley, CA, United States; Department of Molecular & Cell Biology, University of California, Berkeley, CA, United States. Electronic address: schepartz@berkeley.edu.
University of California, Berkeley · USYale University · US

Funding

Studies of Transfer RNAR35GM122560 · NIGMS · YALE UNIVERSITY · PI SOLL, DIETER · 2017 to 2022
$5.6M
NIGMS NIH HHS R35 GM122560
6 · The paper itself

Abstract

With few exceptions, ribosomal protein synthesis begins with methionine (or its derivative N-formyl-methionine) across all domains of life. The role of methionine as the initiating amino acid is dictated by the unique structure of its cognate tRNA known as tRNA

Indexed as

Amino AcidsAmino Acyl-tRNA SynthetasesEscherichia coliPeptidesProteinsRNA, TransferAmino AcidsAmino Acyl-tRNA SynthetasesPeptidesProteinsRNA, TransferChemical biologyGenetically encoded materialsGenetic code expansionNon-canonical amino acidsSynthetic biologyTranslation initiation

Identifiers

PMID34325796
PMCPMC8428779
OpenAlexW3184801864

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.