ArticleBMC genomics2021
Putative genes in alkaloid biosynthesis identified in Dendrobium officinale by correlating the contents of major bioactive metabolites with genes expression between Protocorm-like bodies and leaves.
Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Mechanisms of acclimation regulation and stress response to UV-B inFrontiers in plant science · 2026Article
- Dynamic Changes in Functional Components of Dendrobium officinale and Their Applications in Food Science: A Review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025Review
- Integration of CRISPR/Cas9 with multi-omics technologies to engineer secondary metabolite productions in medicinal plant: Challenges and Prospects.Functional & integrative genomics · 2024Review
- Research progress on the regulatory and pharmacological mechanism of chemical components of Dendrobium.Heliyon · 2024Review
- Multi-omics profiling reveal responses of three majorFrontiers in plant science · 2024Article
- Metabolic Pathway Engineering Improves Dendrobine Production inInternational journal of molecular sciences · 2023Article
- The Integration of the Metabolome and Transcriptome forMolecules (Basel, Switzerland) · 2023Article
- Transcriptomic responses to cold stress inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Suspension culture of somatic embryos for the production of high-value secondary metabolites.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Review
- Integration of high-throughput omics technologies in medicinal plant research: The new era of natural drug discovery.Frontiers in plant science · 2023Review
- A Comparison of the Flavonoid Biosynthesis Mechanisms ofInternational journal of molecular sciences · 2022Article
- Genome-wide identification and characterization of active ingredients related β-Glucosidases in Dendrobium catenatum.BMC genomics · 2022Article
- Light and Potassium Improve the Quality ofMolecules (Basel, Switzerland) · 2022Article
- Integration of Transcriptome and Metabolome Provides New Insights to Flavonoids Biosynthesis inFrontiers in plant science · 2022Article
- A Walk Through the Maze of Secondary Metabolism in Orchids: A Transcriptomic Approach.Frontiers in plant science · 2022Review
- Natural Composition and Biosynthetic Pathways of Alkaloids in MedicinalFrontiers in plant science · 2022Review
- Comparative Proteome and Phosphoproteome Analyses Reveal Different Molecular Mechanism Between Stone Planting Under the Forest and Greenhouse Planting ofFrontiers in plant science · 2022Article
- Transcriptomic analysis of genes related to alkaloid biosynthesis and the regulation mechanism under precursor and methyl jasmonate treatment inFrontiers in plant science · 2022Article
- Bioactivities and Mechanism of Actions ofOxidative medicine and cellular longevity · 2022Review
- ICP-MS based metallomics and GC-MS based metabolomics reveals the physiological and metabolic responses ofFrontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundDendrobium officinale, an endangered Chinese herb, possesses extensive therapeutic effects and contains bioactive ingredients such as major polysaccharides, alkaloids, and minimal flavonoids. We first obtained the protocorm-like bodies (PLBs) of this plant through tissue culture in order to determine the distribution of the main secondary metabolites in each organelle and the PLBs. We then analyzed the correlation between gene expression level from comparative transcriptome sequencing and metabolite content in different organs to identify putative genes encoding enzymes involved in the biosynthesis of polysaccharides, alkaloids, and flavonoids.
resultsWe used seeds as explants for protocorm induction and PLB propagation of D. officinale. The optimal medium formula for PLB propagation was 1/2 MS + α-NAA 0.5 mg·L
conclusionsThe identification of candidate genes encoding enzymes involved in metabolite biosynthesis will help to explore and protect this endangered species and facilitate further analysis of the molecular mechanism of secondary metabolite biosynthesis in D. officinale.
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