ArticleJournal of the American Geriatrics Society2021
A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.
Article in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 28 citations in OpenAlex.
- An Exploratory Stability Selection (ESS) framework for robust predictor discovery: An application to physical resilience in aging populations.Experimental gerontology · 2026Article
- Examining the relevance of gait speed resiliencies to different stressors: the ARIC Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Presurgical immune biomarkers associated with pain intensity and pain interference recovery after total knee arthroplasty: findings from the PRIME-KNEE study.medRxiv : the preprint server for health sciences · 2026Article
- Immune Biomarker Signatures as Predictors of Functional and Pain Recovery After Total Knee Arthroplasty in Older Adults.medRxiv : the preprint server for health sciences · 2026Article
- Clinical predictors of resilience following total knee arthroplasty: the PRIME-KNEE study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Provocative testing in community dwelling older adults: a path to identify physical resilience.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Prediction of postoperative delirium in older adults from preoperative cognition and occipital alpha power from resting-state electroencephalogram.Age and ageing · 2025Observational
- Physical Resilience May Offset Mortality Risks Associated With Genetic Predisposition to Shorter Survival: A Population-based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Characterization of Dynamic Adaptation to Stressors Using Multisystem Stimulus-Response Data: The Study of Physical Resilience in Aging Pilot.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Reserve and Resilience: A Framework to Inform Cardiovascular Disease Outcomes Research Among Older Adults.Circulation. Cardiovascular quality and outcomes · 2025Article
- Stress tests and biomarkers of resilience: Proceedings of the second state of resilience science conference.Journal of the American Geriatrics Society · 2025Article
- The Lived Experiences of Older Adults With Systemic Lupus Erythematosus: Patient Perspectives.The Journal of rheumatology · 2025Article
- From frailty to resilience: exploring adaptive capacity and reserve in older adults-a narrative review.Frontiers in aging · 2025Review
- Building a dynamic adaptational process theory of resilience (ADAPTOR): Stress exposure, reserve capacity, adaptation, and consequence.The American psychologist · 2024Article
- The brain-heart-immune axis: a vago-centric framework for predicting and enhancing resilient recovery in older surgery patients.Bioelectronic medicine · 2024Article
- Trajectories of Physical Resilience Among Older Veterans With Stage 4 CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Preoperative electroencephalographic alpha-power changes with eyes opening are associated with postoperative attention impairment and inattention-related delirium severity.British journal of anaesthesia · 2024Article
- Ageing and physical resilience after health stressors.Stress and health : journal of the International Society for the Investigation of Stress · 2023Article
- An overview of the resilience world: Proceedings of the American Geriatrics Society and National Institute on Aging State of Resilience Science Conference.Journal of the American Geriatrics Society · 2023Article
- A Real-Time Neurophysiologic Stress Test for the Aging Brain: Novel Perioperative and ICU Applications of EEG in Older Surgical Patients.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOlder adults with similar health conditions often experience widely divergent outcomes following health stressors. Variable recovery after a health stressor may be due in part to differences in biological mechanisms at the molecular, cellular, or system level, that are elicited in response to stressors. We describe the PRIME-KNEE study as an example of ongoing research to validate provocative clinical tests and biomarkers that predict resilience to specific health stressors.
methodsPRIME-KNEE is an ongoing, prospective cohort study that will enroll 250 adults ≥60 years undergoing total knee arthroplasty. Data are collected at baseline (pre-surgery), during surgery, daily for 7 days after surgery, and at 1, 2, 4, and 6 months post-surgery. Provocative tests include a cognition-motor dual-task walking test, cerebrovascular reactivity assessed by functional near-infrared spectroscopy, peripheral blood mononuclear cell reactivity ex vivo to lipopolysaccharide toxin and influenza vaccine, and heart rate variability during surgery. Cognitive, psychological, and physical performance batteries are collected at baseline to estimate prestressor reserve. Demographics, medications, comorbidities, and stressor characteristics are abstracted from the electronic medical record and via participant interview. Blood-based biomarkers are collected at baseline and postoperative day 1. Repeated measures after surgery include items from a delirium assessment tool and pain scales administered daily by telephone for 7 days and cognitive change index (participant and informant), lower extremity activities of daily living, pain scales, and step counts assessed by Garmin actigraphy at 1, 2, 4, and 6 months after surgery. Statistical models use these measures to characterize resilience phenotypes and evaluate prestressor clinical indicators associated with poststressor resilience.
conclusionIf PRIME-KNEE validates feasible clinical tests and biomarkers that predict recovery trajectories in older surgical patients, these tools may inform surgical decision-making, guide pre-habilitation efforts, and elucidate mechanisms underlying resilience. This study design could motivate future geriatric research on resilience.
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